Antibodies against PhosphorylcholineImplications for Chronic Inflammatory Diseases

J Frostegård - Metabolites, 2023 - mdpi.com
… We have also studied other chronic inflammatory and/or autoimmune conditions, given the
associations published for IgM anti-PC. Of special interest are conditions with increased risk …

Antibodies against phosphorylcholine and protection against atherosclerosis, cardiovascular disease and chronic inflammation

J Frostegård - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
… and chronic inflammatory conditions are more or less absent in Kitava, Papua New
Guinea[Citation98]. This study population could shed light on the chronic inflammatory diseases in …

… PHOSPHORYLCHOLINE AS PROTECTION MARKERS IN AUTOIMMUNITY, ATHEROSCLEROSIS, CARDIOVASCULAR DISEASE AND CHRONIC INFLAMMATION …

J Frostegård - 2021 - ard.bmj.com
… and cardiovascular disease (CVD) are chronic inflammatory conditions and represent …
conditions. Further, the risk of CVD and atherosclerosis is raised in several autoimmune conditions

Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases

MR de Vries, MM Ewing, RCM de Jong… - Journal of Internal …, 2021 - Wiley Online Library
Phosphorylcholine (PC) is an important pro-inflammatory damage-… protects against
cardiovascular disease. We aimed to develop a monoclonal PC IgG antibody with anti-inflammatory

Different subclasses and isotypes of antibodies against phosphorylcholine in haemodialysis patients: association with mortality

SK Samal, AR Qureshi, M Rahman… - Clinical & …, 2020 - academic.oup.com
Antibodies against phosphorylcholine (anti-PC), especially IgMs, may protect against
chronic inflammatory conditions including atherosclerosis, … The implications are discussed. …

AB0056 NATURAL ANTIBODIES AGAINST PHOSPHORYLCHOLINE AND MALONDIALDEHYDE DURING THE FIRST TWO YEARS OF LIFE: IMPLICATIONS FOR …

D Thiagarajan, S Lundström, G Pershagen… - 2020 - ard.bmj.com
… : Antibodies against phosphorylcholine (anti-PC) have potentially protective properties in both
atherosclerosis and rheumatic disease… most common chronic inflammatory arthritis around …

IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases

D Thiagarajan, N Oparina, S Lundström, R Zubarev… - Scientific reports, 2020 - nature.com
… These findings could have both diagnostic and therapeutic implications, one possibility …
chronic inflammatory disease conditions. It is negatively associated with cardiovascular disease

Antibodies against phosphorylcholine in hospitalized versus non-hospitalized obese subjects

A Jujić, J Korduner, H Holm, G Engström, E Bachus… - Scientific Reports, 2021 - nature.com
… on the role of these antibodies in chronic inflammatory conditions. Most studies have involved
implications for prediction of risk, but also for prevention through immunization with PC. …

IgM anti-phosphorylcholine antibodies associate with senescent and IL-17+ T cells in SLE patients with a pro-inflammatory lipid profile

P López, J Rodríguez-Carrio, A Martínez-Zapico… - …, 2020 - academic.oup.com
Objective The aim was to evaluate whether T cell subsets and the lipid profile could be
linked to the cardioprotective effect of IgM anti-phosphorylcholine (PC) antibodies in SLE. …

Higher levels of anti-phosphorylcholine autoantibodies in early rheumatoid arthritis indicate lower risk of incident cardiovascular events

S Ajeganova, MLE Andersson, J Frostegård… - Arthritis Research & …, 2021 - Springer
… a role for chronic inflammation in atherogenesis, and autoantibodies have been identified as
mediators in the complex inflammatory … and therapeutic implications beyond rheumatology. …