… myokine regulation and putative functions using genetic variation and multi- tissue gene …
We find that in general, expression of myokines do not significantly differ between sexes; …

… , we next assessed putative functions across organs. We … -tissue signaling which occur as a
result of genetic variation 17… between myokine expression levels and global gene expression …

… myokine regarding its deleterious impact on bone remodelling, there are a number of myokine
… inhibition of Sost signalling [49], providing evidence of another putative pathway for its …

… putative, or even already demonstrated as true, myokines have been discovered and studied.
In the present chapter, we will focus in depth on two very relevant myokines… a true myokine. …

… ActRIIB), which activates the SMAD signaling cascade through phosphorylation of SMAD2/3…
the expression of several genes. Myostatin activates also the p38/MAPK signaling, probably …

… myokine that is secreted by contracting skeletal muscle during exercise. Contrary to its putative
pro-… Association of interleukin-15 protein and interleukin15 receptor genetic variation with …

… is so precisely controlled remains a complex biological problem. … to other signaling pathways
members as STATS (Signal … Furthermore, SCFAs are the putative mediators of the effect …

… and biochemical signals, giving rise to bone–muscle crosstalk. They are also known to
secrete osteokines, myokines, and cytokines into the circulation, influencing the biological and …

… simply on genetic variation, clock genes appeared more … putative endocrine factors involved
in muscle-brain signaling, … genes encode proteins known to be secreted as myokines (…

… The myostatin (MSTN) pathway, a prominent muscle- specific regulator of proteostasis, is a
putative signaling … Having ruled out synthesis as an underlying mechanism for the observed …