… to promote RBM39 degradation by CRL4 DCAF15 . We find that DCAF15 adopts a structure
… and engages the second RRM domain of RBM39 with an extended, non-conserved surface …

… The following chapter summarizes our structural investigations around the RBM39-ArSulf-DCAF15
interaction. We conduct immunoprecipitation and pull-down experiments with the …

… Interestingly, E7820-mediated double-strand breaks in DNA … complex assembly between
RBM39 and DCAF15, an adapter … represses cassette exon inclusion and promotes intron …

… glues to recruit RBM39 to the CRL4 DCAF15 E3 ubiquitin … Most protein isoforms for RBM39
contain all four structural … Abl/ABL1, facilitating the transcription coactivation of RBM39 on the …

… that thalidomide promotes proteasomal degradation of the Sal-… -EM structure of the
DDB1–DCAF15–DDA1 bound to RBM39 … DCAF15 or RBM39, and formation of the …

… of DCAF15, and … RBM39 dependence and DCAF15 expression. Here, we demonstrate that
neuroblastoma is both dependent on RBM39 and expresses relatively high levels of DCAF15…

… Inducing proximity among these proteins facilitates the transfer … degron within RBM39 as
well as the residues in DCAF15 that … system for structural and functional studies of RBM39, we …

… an allosteric stabilizer of DCAF15–RBM39 complex or act as … The structural model of
the human DCAF15–E7820–RBM39 … -type way, but rather facilitated the degradation of off-target …

… of RBM39 degradation introduces complex pleiotropic effects that are difficult to untangle. For
example, DCAF15 inhibition, RBM39 degradation, … 1B) are structurally related to indisulam …

… DCAF15 (Figure 4C). Upon docking of dRRM-1 to a published crystal structure of
DDB1ΔB-DDA1-DCAF15-E7820-RBM39, … E3 ligases of interest and facilitate the de novo …