… ligand affinity to the catalytic subunit of human protein kinase CK2. Obtained results revealed
that substitution of baicalein and chrysin with halogen atom increases their binding affinity …

… 3 μM) by blocking the human protein kinase CK2. (19) Typically, … to identify potential
halogenated flavonoids that can inhibit … ring enhanced the binding interaction with the protein …

… between hydrophobicity and binding affinity, however, … protein–ligand complexes indicates
that any increase in ligand hydrophobicity is clearly reflected by an increase in binding affinity…

… responsible for the synthesis of chrysin and its derivatives, such as baicalin and wogonin, in
… of chrysin with chlorine increases the binding affinity to human protein kinase hCK2α, which …

… , as a prodrug enhances its membrane permeability and … effects on CK2, while chrysin (75),
morin (76), baicalein (77), and … Unique activation mechanism of protein kinase CK2. The N-…

… the tumour-associated human protein kinase CK2 have been … was previously reported
to increase their biological activity, it … Comparison to the predicted 13 C shift data of 6,8-Cl-chrysin …

… Baicalein and quercetin are potently active against human … , 11 new chrysin derivatives
were synthesized to increase antiviral … protein kinases (MAPKs), phosphatidylinositol 3-kinase–…

… of the observed increases or decreases in flavonoid activity … derivatives exhibited stronger
antimicrobial activity than baicalin … Hesperetin, luteolin, and chrysin were hydroxylated at the 8 …

… for tumour-associated human kinase CK2 and the observed … under the effect of flavonoids,
we have observed both an increase and a … The substitution of a bromine atom for baicalin (8-…

… knowledge about natural sources of chrysin, its pharmacological activity … halogenation of
natural flavonoids, baicalein and chrysin, enhances their affinity to human protein kinase CK2…