Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta …

JM Park, M Rahmati, SC Lee, JI Shin… - Neural Regeneration …, 2024 - journals.lww.com
… Mesenchymal stem cells have been shown to positively impact motor function and memory
function and protect dopaminergic neurons in preclinical models of Parkinson's disease. …

Behavioral tests in neurotoxin-induced animal models of Parkinson's disease

EM Prasad, SY Hung - Antioxidants, 2020 - mdpi.com
neuronal apoptosis. Since no current treatment can cure PD, using a suitable PD animal
model … different neurotoxin-induced PD animal models with their mechanisms of pathogenesis …

Microglial activation damages dopaminergic neurons through MMP-2/-9-mediated increase of blood-brain barrier permeability in a Parkinson's disease mouse model

Z Ruan, D Zhang, R Huang, W Sun, L Hou… - International journal of …, 2022 - mdpi.com
… of water channel protein aquaporin 4 expressed in astrocyte, a cell component of neurovascular
unit, to BBB reduces brain edema and accelerates functional recovery in rodent models

MPTP neurotoxicity: actions, mechanisms, and animal modeling of Parkinson's disease

M Ferrucci, F Fornai - Handbook of Neurotoxicity, 2021 - Springer
… In fact, the selective neurotoxicity induced by MPTP rejuvenated … Association of Parkinson
disease induction with cardiac … miR-7 and miR-153 protect neurons against MPP(+)-induced …

Intranasal delivery of bone marrow stromal cells preconditioned with Fasudil to treat a mouse model of Parkinson's disease

Y Tang, L Han, X Bai, X Liang, J Zhao… - … Disease and …, 2020 - Taylor & Francis
… This discrepancy between the two studies was perhaps due to different animal models and
… behavioural impairment, protect dopaminergic neurons in MPTP PD mice, and downregulate …

Impact of aging on animal models of Parkinson's disease

IH Klæstrup, MK Just, KL Holm, AKO Alstrup… - Frontiers in aging …, 2022 - frontiersin.org
… (PD), the second most common neurodegenerative disorder. Several animal models have
… , we provide recommendations to manage the challenges related to aged animal models. …

[HTML][HTML] HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 …

Y Lang, Y Li, H Yu, L Lin, X Chen, S Wang… - Aging (albany …, 2020 - ncbi.nlm.nih.gov
… (miR-221-3p)/neuronal pentraxin II (NPTX2) axis in the process of dopaminergic neuron
autophagy using PD mouse models. The PD mouse models were established by intraperitoneal …

Microglial activation mediates noradrenergic locus coeruleus neurodegeneration via complement receptor 3 in a rotenone-induced Parkinson's disease mouse model

L Jing, L Hou, D Zhang, S Li, Z Ruan… - Journal of …, 2021 - Taylor & Francis
… activation and thus protected dopaminergic neurons in a PD rat model generated by … taurine
also attenuated dopaminergic neuronal loss in the PD mouse model generated by paraquat …

[HTML][HTML] CaV1.3 L-Type Calcium Channels Increase the Vulnerability of Substantia Nigra Dopaminergic Neurons in MPTP Mouse Model of Parkinson's Disease

A Verma, V Ravindranath - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
… channel) and Ca V 1.3 42A in mouse SNpc in PD pathogenesis by quantifying mRNA levels
… in their levels in MPTP induced parkinsonism mouse model. Using in situ hybridization and …

[HTML][HTML] Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease

JH Lai, KY Chen, JCC Wu, L Olson, S Brene… - Brain research, 2019 - Elsevier
model (Galter et al., 2010, Shan et al., 2015, Gellhaar et al., 2015). Using the MitoPark mouse
model we … Does vigorous exercise have a neuroprotective effect in Parkinson disease? …