… in vitro and in vivo experimental models mimicking α-synuclein pathology such as oligomerization,
toxicity and … of molecules capable of modulating α-synuclein toxicity. Here, we review …

… , α-synuclein, and mutant Huntingtin which participate in the formation, accumulation,
and deposition of toxic misfolded aggregates… inhibit aggregation of amyloid β, tau, and α-synuclein …

… clearance, and aggravated α-synuclein toxicity. Taken together, our in vitro data demonstrate
that interactions between these two metals and α-synuclein modulate the resulting amyloid …

… the aggregation of α-synuclein in vitro. The aggregation of human recombinant α-synuclein …
Our data demonstrate a significantly increased aggregation propensity of α-synuclein in the …

… prion-like spread of α-syn aggregates, so understanding and limiting α-syn propagation is …
α-syn aggregation and propagation. In this study, we developed an in vitro model using A53T α…

… In the future we plan to confirm the PrP C -clathrin-mediated internalization using in vivo
models and … In conclusion, our data provide in vivo and in vitro evidence supporting a molecular …

… Moreover, the in vitro analysis found that TQ significantly inhibited α-synuclein
aggregation … Thus, TQ not only scavenges the MPTP-induced toxicity but also prevents α-synuclein-fibril …

… in vitro aggregation reaction, cause inflammation and permeabilization of single-liposome
membranes and that larger aggregates are less toxic. Studying soluble aggregates extracted …

… α-Syn-centric treatments for this devastating disease, focusing on those related to α-Syn
aggregation … properties of α-Syn monomers, oligomers, and fibrils in vitro and in vivo. Revealing …

… that aggregates formed both in vitro and in vivo by αS … toxicity, both by stabilized oligomers
generated in vitro and through the formation and toxicity of the aggregates generated in vivo …