[HTML][HTML] Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA …
… Overuse of short-acting β 2 -agonists in asthma is associated with increased risk of
exacerbation and mortality: a nationwide cohort study of the global SABINA programme …
exacerbation and mortality: a nationwide cohort study of the global SABINA programme …
Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation
… Activated B 2 Rs are endocytosed along its agonist (modeled with B 2 R-GFP and CF-εACA-BK,
respectively), while the β-arrestin is translocated from its uniform cytosolic distribution to …
respectively), while the β-arrestin is translocated from its uniform cytosolic distribution to …
Combination of assist use of short-acting beta-2 agonists inhalation and guidance based on patient-specific restrictions in daily behavior: Impact on physical activity of …
T Hirano, K Matsunaga, K Hamada, S Uehara… - Respiratory …, 2019 - Elsevier
… Assist use of inhaled short-acting beta 2 agonists (SABAs) is reportedly effective for preventing
shortness of breath on exertion in chronic obstructive pulmonary disease (COPD) patients…
shortness of breath on exertion in chronic obstructive pulmonary disease (COPD) patients…
β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells
… can be mitigated by treatment with β-AR antagonists, or enhanced by β-AR agonists. This
strongly supports the possibility that reducing stress-induced activation of β2-ARs could help to …
strongly supports the possibility that reducing stress-induced activation of β2-ARs could help to …
[HTML][HTML] Human brown adipocyte thermogenesis is driven by β2-AR stimulation
…, MR Boon, M Fortin, S Phoenix, F Frisch, B Guérin… - Cell metabolism, 2020 - cell.com
… by the stimulation of β 3 -AR. Oral administration of the β 3 -AR agonist mirabegron only
elicited … This led to off-target binding to β 1 -AR and β 2 -AR, thereby increasing cardiovascular …
elicited … This led to off-target binding to β 1 -AR and β 2 -AR, thereby increasing cardiovascular …
Adrenergic receptors and cardiovascular effects of catecholamines
J Motiejunaite, L Amar, E Vidal-Petiot - Annales d'endocrinologie, 2021 - Elsevier
… In addition, a major role of β2 receptors is dilation of coronary arteries in response to stress.
β2 adrenergic agonists are used as mainstay treatments for respiratory diseases such as …
β2 adrenergic agonists are used as mainstay treatments for respiratory diseases such as …
Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists
E Wouters, J Walraed, SD Banister, CP Stove - Biochemical pharmacology, 2019 - Elsevier
… 2) [23], [24]. Several studies have also investigated β-arrestin recruitment by CB 2 , although
… The recruitment of β-arrestin2 to CB 2 has been demonstrated using the PathHunter® and …
… The recruitment of β-arrestin2 to CB 2 has been demonstrated using the PathHunter® and …
Molecular basis for high-affinity agonist binding in GPCRs
T Warne, PC Edwards, AS Doré, AGW Leslie, CG Tate - Science, 2019 - science.org
… β 2 AR(β 1 LBP) converted the behavior of β 2 AR to that of β 1 AR. Adding the converse
residues from β 2 AR into β 1 AR, to make the mutant β 1 AR(β 2 … site in β 1 AR to that of β 2 AR (…
residues from β 2 AR into β 1 AR, to make the mutant β 1 AR(β 2 … site in β 1 AR to that of β 2 AR (…
Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes
MK Thomas, A Nikooienejad, R Bray… - The Journal of …, 2021 - academic.oup.com
… To explore mechanisms by which tirzepatide resulted in greater reductions of hyperglycemia
than a selective GLP-1 receptor agonist, we conducted post hoc exploratory analyses of …
than a selective GLP-1 receptor agonist, we conducted post hoc exploratory analyses of …
SARS-CoV-2 pneumonia in hospitalized asthmatic patients did not induce severe exacerbation
…, C Marcot, G Pamart, B Renaud-Picard… - The Journal of Allergy …, 2020 - Elsevier
… and wheezing requiring systemic corticosteroids and inhaled β2 agonist. … , 2 patients during
p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during …
p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during …
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