[HTML][HTML] Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA …

BI Nwaru, M Ekström, P Hasvold… - European …, 2020 - Eur Respiratory Soc
… Overuse of short-acting β 2 -agonists in asthma is associated with increased risk of
exacerbation and mortality: a nationwide cohort study of the global SABINA programme …

Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation

F Marceau, H Bachelard, J Bouthillier, JP Fortin… - International …, 2020 - Elsevier
… Activated B 2 Rs are endocytosed along its agonist (modeled with B 2 R-GFP and CF-εACA-BK,
respectively), while the β-arrestin is translocated from its uniform cytosolic distribution to …

Combination of assist use of short-acting beta-2 agonists inhalation and guidance based on patient-specific restrictions in daily behavior: Impact on physical activity of …

T Hirano, K Matsunaga, K Hamada, S Uehara… - Respiratory …, 2019 - Elsevier
… Assist use of inhaled short-acting beta 2 agonists (SABAs) is reportedly effective for preventing
shortness of breath on exertion in chronic obstructive pulmonary disease (COPD) patients…

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

…, G Qiao, M Chen, B Dong… - The Journal of …, 2019 - Am Soc Clin Investig
… can be mitigated by treatment with β-AR antagonists, or enhanced by β-AR agonists. This
strongly supports the possibility that reducing stress-induced activation of β2-ARs could help to …

[HTML][HTML] Human brown adipocyte thermogenesis is driven by β2-AR stimulation

…, MR Boon, M Fortin, S Phoenix, F Frisch, B Guérin… - Cell metabolism, 2020 - cell.com
… by the stimulation of β 3 -AR. Oral administration of the β 3 -AR agonist mirabegron only
elicited … This led to off-target binding to β 1 -AR and β 2 -AR, thereby increasing cardiovascular …

Adrenergic receptors and cardiovascular effects of catecholamines

J Motiejunaite, L Amar, E Vidal-Petiot - Annales d'endocrinologie, 2021 - Elsevier
… In addition, a major role of β2 receptors is dilation of coronary arteries in response to stress.
β2 adrenergic agonists are used as mainstay treatments for respiratory diseases such as …

Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists

E Wouters, J Walraed, SD Banister, CP Stove - Biochemical pharmacology, 2019 - Elsevier
2) [23], [24]. Several studies have also investigated β-arrestin recruitment by CB 2 , although
… The recruitment of β-arrestin2 to CB 2 has been demonstrated using the PathHunter® and …

Molecular basis for high-affinity agonist binding in GPCRs

T Warne, PC Edwards, AS Doré, AGW Leslie, CG Tate - Science, 2019 - science.org
β 2 AR(β 1 LBP) converted the behavior of β 2 AR to that of β 1 AR. Adding the converse
residues from β 2 AR into β 1 AR, to make the mutant β 1 AR(β 2 … site in β 1 AR to that of β 2 AR (…

Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes

MK Thomas, A Nikooienejad, R Bray… - The Journal of …, 2021 - academic.oup.com
… To explore mechanisms by which tirzepatide resulted in greater reductions of hyperglycemia
than a selective GLP-1 receptor agonist, we conducted post hoc exploratory analyses of …

SARS-CoV-2 pneumonia in hospitalized asthmatic patients did not induce severe exacerbation

…, C Marcot, G Pamart, B Renaud-Picard… - The Journal of Allergy …, 2020 - Elsevier
… and wheezing requiring systemic corticosteroids and inhaled β2 agonist. … , 2 patients during
p2, and 5 patients were treated with systemic corticosteroids and inhaled β2 agonist during …