Dual bronchodilation for the treatment of COPD: from bench to bedside

M Cazzola, C Page, P Rogliani… - British Journal of …, 2022 - Wiley Online Library
… , is the use of the dual bronchodilation, which is a treatment that … (LAMA) with a long-acting
β 2 -agonist (LABA), rather than a … with dual bronchodilation when they are already taking a β-…

Triple therapy versus dual bronchodilation and inhaled corticosteroids/long-acting β-agonists in COPD: accumulating evidence from network meta-analyses

M Cazzola, L Calzetta, P Rogliani, MG Matera - Pulmonary Therapy, 2019 - Springer
… the role of triple therapy containing a long-acting β-agonist (LABA), a long-acting muscarinic
… population, supporting the role of dual bronchodilation therapy for the treatment of COPD. …

Comparative studies of dual bronchodilation in COPD

M Cazzola, MG Matera, P Rogliani… - Monaldi Archives for …, 2021 - monaldi-archives.org
… of the effectiveness of β2-AR agonists [48]. We were … β-AR blockers and dual bronchodilators
also because there is experimental evidence that the co-administration of a β2-AR agonist

Beyond dual bronchodilation–triple therapy, when and why

M Cazzola, P Rogliani, R Laitano… - … Journal of Chronic …, 2022 - Taylor & Francis
… greater loss of β 2 -ARs than low efficacy agonists, or partial agonists, such as … of β 2 -ARs,
ie, they induce the same maximal response occupying fewer β 2 -ARs than partial agonists to …

Ultra long-acting β-agonists in chronic obstructive pulmonary disease

RM Burkes, RJ Panos - Journal of Experimental Pharmacology, 2020 - Taylor & Francis
Introduction Inhaled β-agonists have been foundational medications for maintenance
COPD management for decades. Through activation of cyclic adenosine monophosphate …

Dual bronchodilator versus inhaled corticosteroid/long-acting β2-agonist in patients with chronic obstructive pulmonary disease: a meta-analysis of randomized …

H Chen, K Wang, T Yuan, X Wang, L Huanng… - International …, 2021 - Elsevier
… Long-acting muscarinic antagonist/long-acting β 2 -agonist (LAMA/LABA, also known as
dual bronchodilator) and inhaled corticosteroid/LABA (ICS/LABA) are the cornerstone of …

Comparison of effectiveness using different dual bronchodilator agents in chronic obstructive pulmonary disease treatment

SL Cheng - Journal of Clinical Medicine, 2021 - mdpi.com
… safety of fixed dual long-acting bronchodilators for chronic … dual bronchodilator agents in
patients with COPD. Patients with diagnosed COPD and treated with a long-acting beta-agonist (…

Triple therapy versus dual or monotherapy with long-acting bronchodilators for chronic obstructive pulmonary disease. A systematic review and meta-analysis

MJ Mammen, DR Lloyd, S Kumar… - Annals of the …, 2020 - atsjournals.org
… therapy compared with long-acting β-agonist/long-acting muscarinic antagonist dual therapy
or monotherapy with a single long-acting bronchodilator in patients with stable COPD who …

Future concepts in bronchodilation for COPD: dual-versus monotherapy

D Singh, JF Donohue, IH Boucot… - European …, 2021 - Eur Respiratory Soc
… or long-acting β 2 -agonist. However, many patients receiving mono-… dual bronchodilation
has greater and consistent efficacy for lung function and symptoms than mono-bronchodilation

A randomized trial of dual-acting bronchodilator AZD8871 for chronic obstructive pulmonary disease

D Singh, R Fuhr, L Jimenez… - American Journal of …, 2019 - atsjournals.org
Dual therapy using long-acting muscarinic antagonists (LAMAs) and long-acting β 2 -agonists
(LABAs) in one inhaler produces superior bronchodilation to monotherapy with either …