Evaluation of methods for adjusting population stratification in genome‐wide association studies: Standard versus categorical principal component analysis
… To evaluate the PCA variants' performance for controlling population stratification, we carry
out two simulation studies under a variety of scenarios of population structures and MAFs to …
out two simulation studies under a variety of scenarios of population structures and MAFs to …
Benefits and limitations of genome-wide association studies
… Association tests are used to identify regions of the genome associated with the phenotype
of interest at genome-wide significance, and meta-analysis is a common step to increase the …
of interest at genome-wide significance, and meta-analysis is a common step to increase the …
Genome-wide association studies
… such as the 1000 Genomes Project or TOPMed 21,22 , which involves the statistical inference
… effects or insufficiently corrected population stratification. In the case of true causal effects, …
… effects or insufficiently corrected population stratification. In the case of true causal effects, …
Evaluation of population stratification adjustment using genome‐wide or exonic variants
… have different levels of confounding by population stratification, we also compare the power
… account for population stratification such as PC-based corrections and mixed-effects models. …
… account for population stratification such as PC-based corrections and mixed-effects models. …
Population structure and pharmacogenomic risk stratification in the United States
… , the likelihood of group-specific effect sizes is far lower than would be expected for non-coding
variants discovered by genome-wide association studies, which are typically tag markers …
variants discovered by genome-wide association studies, which are typically tag markers …
Demographic history mediates the effect of stratification on polygenic scores
AA Zaidi, I Mathieson - Elife, 2020 - elifesciences.org
… Population stratification continues to bias the results of genome-wide association studies
(… We show that the effect of population stratification depends not only on allele frequencies …
(… We show that the effect of population stratification depends not only on allele frequencies …
Robustification of GWAS to explore effective SNPs addressing the challenges of hidden population stratification and polygenic effects
Z Akond, MA Ahsan, M Alam, MNH Mollah - Scientific reports, 2021 - nature.com
… Population stratification is one of the main concerning issues when extensive genome-wide …
the minimum β-divergence method 20,21 . The performance of the proposed approach has …
the minimum β-divergence method 20,21 . The performance of the proposed approach has …
False discovery rate control in genome-wide association studies with population structure
… 1 accounts for population structure because the latter is determined by the genotypes and
… This is akin to using principal components to capture population structure (21), but X − G …
… This is akin to using principal components to capture population structure (21), but X − G …
Structure-informed clustering for population stratification in association studies
… principle underlying Genome Wide Association Studies (GWAS… height in Europeans, we
applied it on the UKBB cohort. We … genome sequences [21]. SDS was combined with GWAS …
applied it on the UKBB cohort. We … genome sequences [21]. SDS was combined with GWAS …
Genome-wide significance thresholds for admixture mapping studies
KE Grinde, LA Brown, AP Reiner, TA Thornton… - The American Journal of …, 2019 - cell.com
… populations with contributions from any number of ancestral populations and arbitrary
population structure. … for obtaining genome-wide significance thresholds for admixture mapping …
population structure. … for obtaining genome-wide significance thresholds for admixture mapping …