Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors
NA Lozinskaya, DA Babkov, EV Zaryanova… - Bioorganic & medicinal …, 2019 - Elsevier
… ATP-competitive inhibitor 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
(SB-216763) 9 was used as a positive control … The results are summarized in Table 3. …
(SB-216763) 9 was used as a positive control … The results are summarized in Table 3. …
[HTML][HTML] Glycogen synthase kinase-3β inhibitor SB216763 promotes DNA repair in ischemic retinal neurons
J Zhang, ZP Lai, P Chen, Y Ying… - Neural Regeneration …, 2021 - journals.lww.com
… The SB216763 group received intraperitoneal injections of SB216763 (0.6 mg/kg) for 3 days,
… -(1-methyl-1H-indol-3-yl)-1H-pyrrole-2, 5-dione (SB216763) is a partial agonist of the aryl …
… -(1-methyl-1H-indol-3-yl)-1H-pyrrole-2, 5-dione (SB216763) is a partial agonist of the aryl …
Indole scaffolds as a promising class of the aryl hydrocarbon receptor ligands
Z Dvořák, K Poulíková, S Mani - European journal of medicinal chemistry, 2021 - Elsevier
… A frequently used inhibitor of glycogen synthase kinase (GSK), SB216763 (V-10), which
is structurally 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, was …
is structurally 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, was …
Glycogen Synthase Kinase-3 modulates α1A-adrenergic receptor action and regulation
R Alcántara-Hernández, G Carmona-Rosas… - European Journal of …, 2020 - Elsevier
… SB-216763 (3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione) was
purchased from Axon Medchem. RPMI medium 1640, Dulbecco’s modified Eagle’s medium, …
purchased from Axon Medchem. RPMI medium 1640, Dulbecco’s modified Eagle’s medium, …
Glycogen synthase kinase-3 inhibitors block morphine-induced locomotor activation, straub tail, and depression of rearing in mice via a possible central action
J Kitanaka, N Kitanaka, K Tomita, FS Hall… - Neurochemical …, 2023 - Springer
… -3 inhibitors SB216763 (3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione)
and AR-A014418 (N-[(4-Methoxyphenyl)methyl]-N′-(5-nitro-2-thiazolyl)urea) were …
and AR-A014418 (N-[(4-Methoxyphenyl)methyl]-N′-(5-nitro-2-thiazolyl)urea) were …
Glycogen synthase kinase-3 inhibitors suppress morphine-induced Straub's tail via a centrally acting mechanism
J Kitanaka, N Kitanaka, K Tomita, FS Hall, K Igarashi… - 2022 - researchsquare.com
… glycogen synthase kinase-3 (GSK-3) inhibitors (SB216763 and … 3 inhibitors SB216763
(3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione) and AR-A014418 (N-[(4…
(3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione) and AR-A014418 (N-[(4…
Role of AMPK in the protective effects exerted by triiodothyronine in ischemic-reperfused myocardium
R Hermann, VEM Cordero, MMF Pazos… - Journal of …, 2021 - jme.bioscientifica.com
Recent studies have provided evidence that triiodothyronine (T3) might play an effective role
in the recovery of ischemic myocardium, through the preservation of mitochondrial function …
in the recovery of ischemic myocardium, through the preservation of mitochondrial function …
[HTML][HTML] Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127
PR Westmark, B Garrone, R Ombrato… - Frontiers in Molecular …, 2021 - frontiersin.org
… Glycogen synthase kinase 3 (GSK3) signals downstream of mGluR 5 and upstream of
FMRP, and its activation affects all major hallmarks of Alzheimer’s disease and FXS (Figure 1). …
FMRP, and its activation affects all major hallmarks of Alzheimer’s disease and FXS (Figure 1). …
GSK-3β inhibitors attenuate the PM2. 5-induced inflammatory response in bronchial epithelial cells
W Zou, D Ye, S Liu, J Hu, T Zhu, F He… - International Journal of …, 2021 - Taylor & Francis
… in the TDZD-8 groups were greater than those in the SB216763 groups. … glycogen synthase
kinase-3 (GSK-3) activity contributes to the pathological processes of COPD. Citation4 GSK3 …
kinase-3 (GSK-3) activity contributes to the pathological processes of COPD. Citation4 GSK3 …
[HTML][HTML] Targeting the Wnt signaling pathway in liver fibrosis for drug options: an update
… 1 (DKK1) or niclosamide, glycogen kinase-3 beta (GSK-3β) using SB-216763, cyclic-AMP …
SB-216763 (3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione) is a …
SB-216763 (3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione) is a …