Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes

P Strączyńska, K Papis, E Morawiec… - Reproductive Biology …, 2022 - Springer
… two-way axis of communication between the oocyte and somatic cells in mammals [36, 89]. …
activity [95]. This research confirms earlier observations on key role of gap junctions in cAMP

cAMP modulators before in vitro maturation decrease DNA damage and boost developmental potential of sheep oocytes

DA Medina-Chávez, I Sánchez-Ajofrín, P Peris-Frau… - Animals, 2021 - mdpi.com
… The cGMP produced diffuses into the oocyte through gap junctions and inhibits the activity of
… To the best of our knowledge, this is the first study to examine the effect of cAMP modulators

Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence

D Richani, RB Gilchrist - Biology of Reproduction, 2022 - academic.oup.com
… before in vitro maturation (IVM) improves oocyte developmental … of cAMP level within the
oocyte (box: [cAMP] modulators), … monkey and human [13, 16, 19, 27–36]. Chemical inhibition of …

Cyclic AMP mediates ovine cumulus–oocyte gap junctional function via balancing connexin 43 expression and phosphorylation

Y Zhao, E Namei, B Yang, X Bao, W Sun… - Endocrine …, 2023 - ec.bioscientifica.com
… phosphorylation on specific sites during in vitro maturation (IVM) (… to the activation of PKA
activity. Subsequently, it regulates … cAMP modulators significantly increased the functional gap

Modulation of phosphatidylinositol 3-kinase activity during in vitro oocyte maturation increases the production of bovine blastocysts

JL Pereira, AG Curcio, LM Barroso… - Zygote, 2020 - cambridge.org
… High intra-oocyte concentrations of cAMP maintain the oocyte … However, during in vitro
maturation (IVM), the activity of various … effect of PI3K activity regulation on MPF activity, kinetics of …

Effect of Cyclic Adenosine Monophosphate on Connexin 37 Expression in Sheep Cumulus-Oocyte Complexes

M Zhao, G Subudeng, Y Zhao, S Hao, H Li - Journal of Developmental …, 2024 - mdpi.com
… of cAMP in multi-species oocytes during in vitro maturation can … explored the possible effects
of cAMP modulators on the … of cAMP on PKA activity and significantly downregulating the …

Effects of cyclic adenosine monophosphate modulators on maturation and quality of vitrified-warmed germinal vesicle stage mouse oocytes

D Lee, HH Lee, JR Lee, CS Suh, SH Kim… - Reproductive Biology and …, 2020 - Springer
… monophosphate (cAMP) modulators to in vitro maturation (IVM… The elevated cAMP inhibits
the activity of protein kinase A, … process of F-actin and microtubule [35,36,37]. Therefore, it is …

Melatonin improves the maturation and developmental ability of bovine oocytes by up-regulating GJA4 to enhance gap junction intercellular communication

T Hao, X Xu, H Hao, W Du, Y Pang… - … and Development, 2021 - CSIRO Publishing
… bovine oocytes, and isoprenaline (enhancer of gap junctional … investigate the effect of MT
on GJIC activity in bovine oocytes. … effect of MT on oocyte quality during IVM, the cAMP level in …

The ERβ-cAMP signaling pathway regulates estradiol-induced ovine oocyte meiotic arrest

B Yang, Y An, Y Yang, Y Zhao, K Yu, Y Weng, C Du… - Theriogenology, 2024 - Elsevier
… the IVM of oocytes, IVM is still less efficient than in vivo maturation [3]… levels in HeLa cells
and stimulated the transcriptional activity … monophosphate modulators during in vitro maturation

Effects of cyclic adenosine monophosphate modulating agents during oocyte pre-maturation and the role of melatonin on in vitro maturation of bovine cumulus-oocyte …

BR Silva, LG Barrozo, DR Nascimento, FC Costa… - Animal Reproduction …, 2023 - Elsevier
… the effects of different combinations of cAMP modulating agents … collected from bovine
ovaries (n = 36) and pre-matured in TCM-… Mitochondrial activity in matured oocytes with different …