… tyrosinase levels.11 Since the two molecules have different mechanisms of action, 4nBR, a
strong tyrosinase inhibitor, … both transcriptional and post-transcriptional process of tyrosinase. …

… 4-Butylresorcinol, also known as rucinol, is a highly effective … there is a necessity that
tyrosinase inhibitors should also be … use of a 0.3% 4-n-butylresorcinol cream instead of the widely …

… The product also demonstrated very good skin tolerability. … Exclusion criteria included: (i)
use of topical retinoids during … over other tyrosinase inhibitors for the treatment of age spots, …

… melanocytes, inhibiting tyrosinase and mitochondrial … of resorcinol that inhibits tyrosinase
and tyrosinase related … efficacy of topical azelaic acid, 4-n butyl resorcinol and retinol …

… 4-butylresorcinol or 4-hexylresorcinol, also exhibited very low IC 50 values (Figure 19),
particularly against the monophenolase activity (IC 50 = 0.077 μM for 4-butylresorcinol… )-2,3-bis(4-…

… [1] F Stab L, Mann T, Gerwat W, Batzer J, Ahlheit S, Scherner C, et al. 4-n-butylresorcinol,
a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. J EUR …

… The most successful therapy so far is so-called the … 4-n-butyl-resorcinol was selected as a
tyrosinase inhibitor in … requires long-term treatment by the existing topical agents on the market …

… as it is the most effective means to reduce melanogenesis. … topical tyrosinase inhibitors that
have proven efficacy on the … -butylresorcinol which evidently has higher efficacy than arbutin …

… -HR is one of the most potent tyrosinase inhibitors. The combination of … , and the test product
was applied topically in a volume of 10 µl. Controls were not treated. The change in media …

… 4-n-butyl resorcinol proved to be very effective as a human tyrosinase inhibitor with an IC50
value of 21 lmol/L and 4… as well as the route of topical administration, so a delivery form is …