The interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice

LT Lopes, L Canto-de-Souza… - Behavioural Brain …, 2022 - Elsevier
… The periaqueductal gray matter (PAG) is a midbrain structure … 5-HT 3 R activation in the
dPAG does not change anxiety-like … of 5-HT2 receptors in the periaqueductal grey matter (PAG) …

Defensive and emotional behavior modulation by serotonin in the periaqueductal gray

P Vázquez-León, A Miranda-Páez… - Cellular and Molecular …, 2023 - Springer
… by the activation of 5-HT 1A and 5-HT 2A/C receptors and their … -HT 2C receptors in the
dPAG play an opposite role in anxiety-like … The dPAG is a midbrain area rich in brain-derived …

Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in …

D Baptista-de-Souza, LRR Tavares… - Frontiers in …, 2020 - frontiersin.org
… such as the amygdala and periaqueductal gray (PAG). Acute … of 5-HT 2C receptors and
5-HT levels whereas reduced its … through activation of 5-HT 2C receptors in this forebrain area. …

Serotonin in Fear and Anxiety

M Hagsäter - 2020 - gupea.ub.gu.se
… of the ventral periaqueductal gray (vPAG) decreases when the … Similarly, reduced anxiety-like
behaviour has been observed … mediated by stimulation of 5-HT2 and 5-HT3 receptors. …

Serotonin mediates the panicolytic-like effect of oxytocin in the dorsal periaqueductal gray

T De Oliveira Sergio, AT Frias… - Journal of …, 2020 - journals.sagepub.com
… For instance, intracerebroventricular injection of OT reduces anxiety in the rat social … that
in this midbrain area, 5-HT, via activation of 5-HT 1A or 5-HT 2A receptors, inhibits escape …

The modulatory role of serotonin-1A receptors of the basolateral amygdala and dorsal periaqueductal gray on the impact of hormonal variation on the conditioned fear …

RF Sgobbi, RM Incrocci, F Paliarin, MJ Nobre - Neuroscience, 2024 - Elsevier
… stimuli into low or high anxiety-like subjects. The baseline … to reduce startle potentiation,
most likely by activating the … Because PAG is downstream from the amygdala and the main …

Fear and anxiety disorders–interaction of AVP and OXT brain systems with the serotonergic system

CS Hamann - 2023 - opus.bibliothek.uni-wuerzburg.de
… 5-Htt gene is associated with increased anxiety-like behavior. High amounts of stress …
medulla oblongata and caudal pons, whereas the rostral raphe complex is located in the midbrain

The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception

LL Falconi-Sobrinho, T dos Anjos-Garcia, MA Rebelo… - …, 2024 - Elsevier
… the dorsal periaqueductal grey matter (dPAG), a midbrain structure … panic test displayed
anxiety-like risk assessment reactions, … Activation of ACC 24b area NMDA receptors facilitated …

Cannabinoid CB1 receptors mediate the anxiolytic effects induced by systemic alprazolam and intra-periaqueductal gray 5-HT1A receptor activation

LA Batista, FA Moreira - Neuroscience letters, 2019 - Elsevier
… possibly due to activation of CB 1 receptors in encephalic regions … , and the periaqueductal
gray matter (PAG) [10,18]. … can promote anxiety-like behavior and decrease panic-like …

Orchestration of innate and conditioned defensive actions by the periaqueductal gray

FMCV Reis, D Mobbs, NS Canteras, A Adhikari - Neuropharmacology, 2023 - Elsevier
… The midbrain periaqueductal gray (PAG) has been … -1A (5-HT1A) or 5-HT2 receptors agonists
in the dorsal PAG can produce … the degree of the dorsal PAG activation, we may predict the …