Application of Bayesian approaches in drug development: starting a virtuous cycle
SJ Ruberg, F Beckers, R Hemmings, P Honig… - Nature Reviews Drug …, 2023 - nature.com
… To obtain the best experience, we recommend you use a more up … time, can be well suited
for the use of Bayesian statistical … We then explore the barriers to their wider use and present a …
for the use of Bayesian statistical … We then explore the barriers to their wider use and present a …
A Bayesian machine learning approach for drug target identification using diverse data types
NS Madhukar, PK Khade, L Huang, K Gayvert… - Nature …, 2019 - nature.com
… Computational approaches have the potential to … To see how our novel predictions related
to known microtubule-… database 25 we extracted the “preferred term” side effects for each drug…
to known microtubule-… database 25 we extracted the “preferred term” side effects for each drug…
A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model
AD Blanchette, SD Burnett, FA Grimm… - Toxicological …, 2020 - academic.oup.com
… in this study the benefits of using Bayesian approaches in … a combined experimental-computational
approach to quantify … action potential duration, rather than measures of viability such …
approach to quantify … action potential duration, rather than measures of viability such …
Machine Learning Approach to Predict AXL Kinase Inhibitor Activity for Cancer Drug Discovery Using XGBoost and Bayesian Optimization
… long time to complete [37,38]. … study introduces a sophisticated computational approach to
cancer drug discovery by leveraging an XGBoost model enhanced with Bayesian Optimization …
cancer drug discovery by leveraging an XGBoost model enhanced with Bayesian Optimization …
Practical parameter identifiability for spatio-temporal models of cell invasion
MJ Simpson, RE Baker… - Journal of the …, 2020 - royalsocietypublishing.org
… We examine the practical identifiability of parameters in a … probes to show real-time
progression through the cell cycle [4]. … using an optimization-based, profile likelihood approach. In …
progression through the cell cycle [4]. … using an optimization-based, profile likelihood approach. In …
Cancer classification from time series microarray data through regulatory dynamic bayesian networks
… graphs, and either return the best one found (a point estimate), or … Our computational approach
reveals the importance of … In the present study we employed time series microarray gene …
reveals the importance of … In the present study we employed time series microarray gene …
An optimal time for treatment—predicting circadian time by machine learning and mathematical modelling
… The administration time can be best coordinated to the daily … as an effective treatment
optimization tool, which could increase … For time-domain approaches, the time series is explored …
optimization tool, which could increase … For time-domain approaches, the time series is explored …
A comprehensive review of computational cell cycle models in guiding cancer treatment strategies
C Ma, E Gurkan-Cavusoglu - npj Systems Biology and Applications, 2024 - nature.com
… Additionally, we explore how computational approaches help … ancestor at time zero, which
lives for a certain period before … best fit of an Erlang distribution to the experimental cell cycle …
lives for a certain period before … best fit of an Erlang distribution to the experimental cell cycle …
Population modeling of tumor growth curves and the reduced Gompertz model improve prediction of the age of experimental tumors
C Vaghi, A Rodallec, R Fanciullino… - PLoS computational …, 2020 - journals.plos.org
… the best results, with drastic improvements when using Bayesian … All LM2-4 LUC+ implanted
animals used in this study are vehicle… The number of injected cells at time t inj = 0 was 10 6 , …
animals used in this study are vehicle… The number of injected cells at time t inj = 0 was 10 6 , …
Computational prediction of gene regulatory networks in plant growth and development
… This review summarizes recent computational approaches applied … a period of time to study
growth and development (eg time … Thus, an integrative approach is strongly recommended to …
growth and development (eg time … Thus, an integrative approach is strongly recommended to …