… Unlike its mammalian homolog, we find Drosophila Mrj is neither an essential gene nor …
expanded poly Glutamine aggregates in the brain and could rescue its toxicity in the Drosophila …

… protein, DNAJB6 (MRJ), shown to potently inhibit the aggregation of … Over-expression of the
ER localized Hsc70 homolog BIP [137… of the role aggregates play in polyQ protein toxicity is …

… Unlike its mammalian homolog, we find Drosophila Mrj is neither an essential gene nor …
expanded poly Glutamine aggregates in the brain and could rescue its toxicity in the Drosophila …

… of the differential toxicity of the aggregation process and/or its … Drosophila (involving the
JDP DnaJ-1, a putative ortholog of … whether MRJ is the true fly equivalent of human DNAJB6, …

… The expression of disease-associated polyglutamine … aggregates of polyQ or the resident
prions [40,99,100,101,102]. Overexpressing Ydj1 or Sis1 was found to modulate the toxicity of …

… Here we have tested the hypothesis that modulation of Hsp70 … , for example mrj, a gene
that encodes an orthologue of a … aggregation, 60 while DnaJ-1 can suppress poly glutamine (…

… UIMs modulate toxicity of the isolated polyQ of ataxin-3. (A) … ortholog, HSPA8, indicate that
it can suppress aggregation … the HSP40 members Dnaj and mrj, and the HSP70 members …

… aggregates of polyQ or the resident prions [40,99–102]. Overexpressing Ydj1 or Sis1 was
found to modulate the toxicity … Suppression of polyglutamine toxicity by a Drosophila homolog …

… NDs-associated aggregates and their toxicity in cells and the … aggregates are found in the
brain of patients: Polyglutamine (… further aggravates aggregation of proteins by modulating the …

… Alpha-synuclein immunoreactivity of huntingtin polyglutamine aggregates in striatum and …
in intracellular inclusions and modulates its aggregation, secretion and toxicity. Hum. Mol. …