Clinically Relevant Drug-Induced Myopathies

A Burke-Doe - Topics in Geriatric Rehabilitation, 2019 - journals.lww.com
Clinically identified myopathies can occur with administration of medications such as statins,
glucocorticoids, antibiotics, antirheumatics, and retinoids. While the frequency of drug-…

CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential

IR Schlaepfer, M Joshi - Endocrinology, 2020 - academic.oup.com
… the concomitanttreated with Perhexiline over 12 months for ischemia and/or heart failure.
Their results showed incremental evidence on the safety of Perhexiline in long-term treatments

Muscle toxicity of drugs: when drugs turn physiology into pathophysiology

L Janssen, NAE Allard, CGJ Saris… - Physiological …, 2020 - journals.physiology.org
… In this review, we use the term myopathy to reflect upon the whole range of muscle
complaints that can be evoked by drugs. We will clearly specify if the muscle symptoms are …

Side effects of beta adrenergic antagonists and antianginal drugs

LM Stever, AN Ali, LB Chambers… - Side Effects of Drugs …, 2022 - Elsevier
… This case report suggests that medication therapy may not … to elucidate the mechanism of
perhexiline's toxicity in human … He was taking amiodarone and pravastatin for 1 year which …

[HTML][HTML] A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection

M Rienzo, J Imbault, Y El Boustani, A Beurton… - Scientific Reports, 2020 - nature.com
… Heart rhythm irregularities were prevented by using continuous infusion of amiodarone (1 …
Boston, MA, USA) was performed concomitant to hemodynamic data collection at each point of …

[HTML][HTML] Diagnosis and management of secondary causes of steatohepatitis

R Liebe, I Esposito, HH Bock, S Vom Dahl, J Stindt… - Journal of …, 2021 - Elsevier
… and steatohepatitis development include amiodarone, diltiazem, … This class of drugs
comprises amiodarone, perhexiline, … A recent case series of 34 patients with anorexia nervosa …

Drug-Induced Disorders of the Autonomic Nervous System

KK Jain, KK Jain - Drug-induced Neurological Disorders, 2021 - Springer
… A case-control study has shown that exposure to several types of strong anticholinergic
drugs is associated with an increased risk of dementia and the attributable fraction associated …

[HTML][HTML] Impairment of anti-aggregatory responses to nitric oxide and prostacyclin: Mechanisms and clinical implications in cardiovascular disease

YY Chirkov, TH Nguyen, JD Horowitz - International Journal of Molecular …, 2022 - mdpi.com
… 2 is exaggerated in the presence of concomitant obesity [78]. An … ACS [130], that therapy
with perhexiline for three days was … also occurred after perhexiline therapy in patients with SAP …

Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies

A González-Duarte, A Varma-Doyle… - Current Opinion in …, 2021 - journals.lww.com
… Subclinical or clinically evident hyposmia is a frequent concomitant feature in PAF patients
[… include the antiarrhythmic agent, amiodarone, the coronary vasodilator, perhexiline, and the …

Clinical consequences of drug-induced mitochondrial dysfunction

RL Jensen, RT Kiy, FFB Dayel, AE Chadwick - Mitochondrial Intoxication, 2023 - Elsevier
… Research has shown that drugs such as perhexiline, amiodarone, and tamoxifen can
accumulate in the mitochondria and can interfere with some processes including the electron …