Cancer prevention and therapy of two types of gap junctional intercellular communication–deficient “cancer stem cell”

JE Trosko - Cancers, 2019 - mdpi.com
… with a lack of gap junctional intercellular communication (GJIC)… activated oncogenes, which
block gap junction function, provide … This complex method of integrating extra-, intra- and gap

Electrical Communication and its Physiological Relevance in Retinal Pigment Epithelium

J Fadjukov - 2023 - trepo.tuni.fi
… Running has become an integral part of my creative process and problem-solving, and I …
intercellular communication mediating gap junctions are involved in the phagocytosis process. …

GAP junctions: multifaceted regulators of neuronal differentiation

S Talukdar, L Emdad, SK Das, PB Fisher - Tissue Barriers, 2022 - Taylor & Francis
… HCs assist in the communication between intra- and extracellular compartments thereby …
Citation3,Citation11 Thus, gap junctional intercellular communication (GJIC) creates cortical …

… multiparametric scrape loading-dye transfer assay for a simultaneous high-throughput analysis of gap junctional intercellular communication, cell density and viability

A Dydowiczová, O Brózman, P Babica… - Scientific Reports, 2020 - nature.com
… Their opening is regulated by various physiological and pathological conditions, offering
a diffusional transmembrane route between the intra and extracellular milieus 40 . Although …

A new path to mental disorders: Through gap junction channels and hemichannels

A Zlomuzica, L Plank, E Dere - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
… , as well general aberrations in neuronal and glial gap junctional coupling (Table 1). The …
the empirical and theoretical evidence at hand that suggests a prominent role of gap junction …

Synchronization of bioelectric oscillations in networks of nonexcitable cells: from single-cell to multicellular states

J Cervera, JA Manzanares, S Mafe… - The Journal of Physical …, 2019 - ACS Publications
… There exists a significant interplay between the bioelectrical and biochemical signals of
nonexcitable cells both at the intra- and intercellular levels, though the mechanisms involved are …

On the potential origin and characteristics of cancer stem cells

JE Trosko - Carcinogenesis, 2021 - academic.oup.com
… for tumor promotion included the inhibition of gap junctional intercellular communication. …
mechanisms involving the integration of extra-, intra- and inter-cellular communication (52). …

Glial connexins and pannexins in the healthy and diseased brain

C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
… via unique channels called gap junctions (GJs) was … communication supporting electrical
and biochemical/metabolic coupling, referred to as gap junctional intercellular communication (…

In Search of a Unifying Concept in Human Diseases

JE Trosko - Diseases, 2021 - mdpi.com
… access to the later discovery of gap junctional intercellular communication (GJIC). In addition…
of the integrated extra-, intra- and gap junctional intercellular communication processes, to …

Applicability of scrape loading-dye transfer assay for non-genotoxic carcinogen testing

I Sovadinová, BL Upham, JE Trosko… - International Journal of …, 2021 - mdpi.com
… to disrupt gap junctional intercellular communication (GJIC), as … , GJIC-dependent integration
of various extra-, intra- and inter-… of signal integration and intercellular communication are …