… In the CNS, C1q plays a role in synaptic pruning during CNS development process [10]. … ,
the dramatic increases of C1q protein have been detected in the brains of normally aging mice …

… double staining of C1q and glial fibrillary acidic protein (GFAP) … dramatically increases
with normal aging. The expression of C1q at a young age can be related to its function during …

… protein, can opsonize neurons and is recognized by microglia by means of its C3 receptor.
Furthermore, the C1q protein … β-amyloid (Aβ) a significant increase of C1q levels occurred [8]. …

… C1q, C3, and C4, as well as the complement proteins C1q … , especially as age increases
and the degree of brain damage … However, due to its rapid growth rate and poor treatment …

… C1q in the microglia was also seen in the aged mouse brain [… in initiating complement signaling
in the aged brain. Given the … a significant increase in the C1qA levels in aged rats (Fig. 7A…

… alterations in CNS complement cascade proteins (C1q, C3), TLR4… knockdown of microglial
C1q by 8 weeks of age, in absence of … depletion of C1q in the brain without altering C1q in the …

… Such deleterious effects are part and parcel of the aging process [52]. C1qbp (C1q binding
protein) is a mitochondrial protein. A study suggests a specific function of C1qbp in the brain …

… proteins are increased in Tau P301S synapse fractions with … brain volume longitudinally at
3, 6 and 9 months of age. … KO versus WT hippocampi, we observed a significant increase in …

… Table 3, there was a significant increase in C1q-PSD95 … C1q and CD47 favors phagocytosis
conditions during aging, we investigated whether microglia morphology changed with age …

… humoral response, through initiating proteins such as C1q that bind … proteins are also made
within the normal and diseased CNS … homeostatic processes during development and aging. …