… The µ-opioid receptor (coded by OPRM1) is primarily expressed in the brain, where it
mediates the rewarding effects of opioids and other drugs of abuse by modulating the dopamine …

… One hypothesized moderator of naltrexone's effects in AUD is rs1799971, a single-nucleotide
polymorphism (SNP) in the μ-opioid receptor gene (OPRM1). The mu-opioid receptor …

… polymorphisms (SNPs) in the opioid receptor delta 1 (OPRD1) gene coding region are
associated with treatment responses … [36], related to μ-opioid receptor desensitization, was found …

… The OPRD1gene located on chromosome 1, while the OPRK1 gene located on chromosome
8 [14]. Activation of the μ-opioid receptor and δ-opioid receptor mediate drug rewarding …

… related behavioural changes. The OPRM1 gene SNP A118G encodes µ opioid receptor’s …
with OPRM1 A118G polymorphism respond well to naltrexone treatment compared to patients …

… introduction of naltrexone corresponded … associated with a stronger response to naltrexone
for patients with an alcohol use disorder. Although studies are inconclusive so far, naltrexone …

… An evaluation of μ-opioid receptor (OPRM1) as a predictor of naltrexone response in the
treatment of alcohol dependence: results from the Combined Pharmacotherapies and …

… (MATs): buprenorphine, methadone or naltrexone. Untreated individuals are prone to …
The OPRM1 gene located on chromosome 6q24-q25 encodes the µ opioid receptor, which …

… A, Saarelainen K et al (2006) μ Opioid receptor A118G polymorphism in association with
striatal opioid neuropeptide gene expression in heroin abusers. Proceedings of the National …

… high efficacy at the µ-opioid receptor and low efficacy at the κ-opioid receptor [14], … genes
given that OPRM1 encodes the µ-opioid receptor, OPRK1 encodes the κ-opioid receptor, and …