The InterPro protein families and domains database: 20 years on

M Blum, HY Chang, S Chuguransky… - Nucleic acids …, 2021 - academic.oup.com
… InterPro combines signatures representing equivalent families, … for protein classification.
Founded in 1999, InterPro has become one of the most widely used resources for protein family

The Pfam protein families database in 2019

S El-Gebali, J Mistry, A Bateman, SR Eddy… - Nucleic acids …, 2019 - academic.oup.com
… Despite our continual efforts to rename DUFs based on functional information found in both
the scientific literature and other protein family databases (22), the fraction of Pfam entries …

Pfam: The protein families database in 2021

J Mistry, S Chuguransky, L Williams… - Nucleic acids …, 2021 - academic.oup.com
… a database of protein families and domains that is widely used to analyse novel genomes, …
of unknown function (DUF) and uncharacterized protein families (UPF). Over time the …

RefSeq: expanding the Prokaryotic Genome Annotation Pipeline reach with protein family model curation

W Li, KR O'Neill, DH Haft, M DiCuccio… - Nucleic acids …, 2021 - academic.oup.com
… In order to promote their use in contexts beyond PGAP, we have built the Protein Family
Models Entrez database, a database that contains HMMs, BlastRules and CDD architectures, …

Dali server: structural unification of protein families

L Holm - Nucleic acids research, 2022 - academic.oup.com
protein families for which no structural information existed. The Dali server for 3D protein
, (ii) structural alignments are annotated with protein families. Using these new features, we …

Glutathione S-transferase: a versatile protein family

S Vaish, D Gupta, R Mehrotra, S Mehrotra… - 3 Biotech, 2020 - Springer
… GSTs are a huge gene family of multidisciplinary functions. The GST protein family consists
of three members: cytosolic GSTs, mitochondrial GSTs, and microsomal GSTs. Among them, …

The gasdermins, a protein family executing cell death and inflammation

P Broz, P Pelegrín, F Shao - Nature Reviews Immunology, 2020 - nature.com
… , we discuss the latest insights into gasdermin activation and regulation, the assembly of the
gasdermin pore and pyroptosis-related biological functions of the gasdermin protein family. …

[HTML][HTML] The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes

NJ Haywood, TA Slater, CJ Matthews… - Molecular metabolism, 2019 - Elsevier
… Finally, within the axis there is a family of 6 IGF-I binding proteins named IGFBP-1-6 and
several families of binding protein proteases that regulate the binding proteins. …

Microbial genome analysis: the COG approach

MY Galperin, DM Kristensen… - Briefings in …, 2019 - academic.oup.com
genome annotation and comparative genomics. Initially created for the purpose of evolutionary
classification of protein families, the … genomes, for such tasks as (i) unification of genome

PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API

H Mi, D Ebert, A Muruganujan, C Mills… - Nucleic acids …, 2021 - academic.oup.com
protein families, and include all members of each family in 142 fully sequenced genomes. …
, high-level classification of the functions of proteins and protein families (1). On the PANTHER …