A guide to interrogating immunometabolism

K Voss, HS Hong, JE Bader, A Sugiura… - Nature Reviews …, 2021 - nature.com
… We offer recommendations for initial approaches to develop and test metabolic hypotheses
… demonstrating the power of these metabolic approaches to uncover the role of metabolism in …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
… An important step in energy metabolism is the hydrolysis of triglycerides (TG) in lipid droplets
to release fatty acids that can be used or stored [10]. Abnormal lipid metabolism can lead to …

An integrative systems genetic analysis of mammalian lipid metabolism

BL Parker, AC Calkin, MM Seldin, MF Keating… - Nature, 2019 - nature.com
… Collectively, our study serves as a rich resource for probing mammalian lipid metabolism
and provides opportunities for the discovery of therapeutic agents and biomarkers in the setting …

[HTML][HTML] What is the best housing temperature to translate mouse experiments to humans?

J Keijer, M Li, JR Speakman - Molecular metabolism, 2019 - Elsevier
energy metabolism in a body size dependent manner. This has implications for the housing
temperature at which mice … Here, we measured energy metabolism of C57BL/6 mice over a …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

ECB Johnson, EB Dammer, DM Duong, L Ping… - Nature medicine, 2020 - nature.com
… In summary, multiple M4 astrocyte/microglial metabolism module protein members could
be measured in human CSF by MS without fractionation or previous depletion of highly …

Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

C Vicente-Gutierrez, N Bonora, V Bobo-Jimenez… - … metabolism, 2019 - nature.com
… regulators of brain metabolism and neuronal function. We generated mice that inducibly …
, immunohistochemical and behavioural analysis of these mice revealed alterations in brain …

Adipose tissue NAD+ biosynthesis is required for regulating adaptive thermogenesis and whole-body energy homeostasis in mice

S Yamaguchi, MP Franczyk… - Proceedings of the …, 2019 - National Acad Sciences
… possibility that NMN administration affects energy metabolism in other metabolic organs (12,
13… is an important regulator of thermogenesis and whole-body energy metabolism (Fig. 6H). …

SCENITH: a flow cytometry-based method to functionally profile energy metabolism with single-cell resolution

RJ Argüello, AJ Combes, R Char, JP Gigan, AI Baaziz… - Cell metabolism, 2020 - cell.com
… method for complex metabolic profiling with single-cell resolution based on PS levels as
the readout. We termed this method SCENITH (single-cell energetic metabolism by profiling …

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice

C Depommier, M Van Hul, A Everard, NM Delzenne… - Gut …, 2020 - Taylor & Francis
… by using specific bacteria to control whole-body energy metabolism. … energy metabolism
by using indirect calorimetry, and the effect of pasteurized A. muciniphila on whole-body energy

A metabolome atlas of the aging mouse brain

J Ding, J Ji, Z Rabow, T Shen, J Folz… - Nature …, 2021 - nature.com
… We show that metabolic changes can be mapped to existing gene and protein brain atlases.
The brain metabolome atlas is publicly available (https://mouse.atlas.metabolomics.us/) and …