3D tumor models for breast cancer: Whither we are and what we need

GM Balachander, R Kotcherlakota… - ACS Biomaterials …, 2021 - ACS Publications
… escalated the development of three-dimensional models (3D) as … However, during sprouting
angiogenesis TGF-β1 and … demonstrated using a 3D sprouting angiogenesis assay. The …

Porcine arterial ECM hydrogel: Designing an in vitro angiogenesis model for long‐term high‐throughput research

T Davidov, Y Efraim, N Dahan, L Baruch… - The FASEB …, 2020 - Wiley Online Library
… tailored into a three-dimensional model of angiogenesis using … effectors of angiogenesis,
the model measures reflected the … but synergistically regulate sprout angiogenesis of human …

Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro

SR Moses, JJ Adorno, AF Palmer… - American Journal of …, 2021 - journals.physiology.org
… Most conventional in vitro models lack the three-dimensional (… blood flow to avascular,
ischemic, or growing tissue (46, 47). … is coincident with sprouting angiogenesis that is especially …

[HTML][HTML] Three-dimensional tumor growth in time-varying chemical fields: a modeling framework and theoretical study

M Antonopoulos, D Dionysiou, G Stamatakos… - BMC …, 2019 - Springer
… 2-dimensional simulations which additionally considered angiogenesis, necrosis and … of
the effects of model parameters on the number of live cancer cells of a growing tumor has been …

[HTML][HTML] A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth

MR Nikmaneshi, B Firoozabadi, A Mozafari, LL Munn - Scientific reports, 2020 - nature.com
… wall to create sprouts in the initial stage of angiogenesis 33,… model that recapitulates a
three-dimensional TME to better understand the transition from avascular growth to angiogenesis

Three-dimensional induced pluripotent stem-cell models of human brain angiogenesis

P Searson, RM Linville, D Arevalo, JC Maressa… - 2019 - researchsquare.com
… [27], we apply optimized angiogenic factors to promote sprouting and … three-dimensional
models provide a diverse toolbox for studies of developmental and pathological angiogenesis

[HTML][HTML] Multiscale modeling of human cerebrovasculature: A hybrid approach using image-based geometry and a mathematical algorithm

S Ii, H Kitade, S Ishida, Y Imai… - PLoS computational …, 2020 - journals.plos.org
… 3-D region growing according to the minimum and … modeling, to appropriately address the
three-dimensional spatial distribution of the cerebrovasculature for the blood flow simulations

Key components of engineering vascularized 3-dimensional bioprinted bone constructs

F Shahabipour, N Ashammakhi, RK Oskuee… - Translational …, 2020 - Elsevier
Three-dimensional (3D) … by sprouting can occur as a response to local cues derived from
hypoxic and tumorigenic tissues. There are two events which underlie sprouting angiogenesis, …

[HTML][HTML] 3D cancer models: Depicting cellular crosstalk within the tumour microenvironment

T Franchi-Mendes, R Eduardo, G Domenici, C Brito - Cancers, 2021 - mdpi.com
… culture) in a three-dimensional configuration to better represent … perspectives on the 3D
modelling strategies and their potential … The spheroids exhibited signs of sprouting angiogenesis

A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity

AO Lampejo, SE Lightsey, MC Gomes… - Annals of Biomedical …, 2024 - Springer
… two-dimensional (2D) or three-dimensional (3D), with 3D in … or fibroblasts to aid in angiogenic
sprout formation, as well as … were shown to have a stronger angiogenic effect in our initial …