… of SUMO pathway inhibition in cancer patients. In this comprehensive review, we critically
discuss the potential of targeting the SUMO pathway as a therapeutic option for cancer. …

… of the SUMO pathway in PDAC. We will describe the known functions of the SUMO pathway
in … We will explain how the SUMO pathway is connected to the MYC oncogene and how this …

… Table 1 SUMO pathway components … This Review discusses the mechanisms of SUMO
conjugation to proteins … Mechanistically, inhibition of transcription factors by sumoylation can be …

… However, the latter could be reactivated by pro-oxidants or by inhibition of the SUMO
pathway using either a pharmacological inhibitor of SUMOylation (anacardic acid) or RNA …

… )ylation and blocking SUMOylation consequently inhibits cell … activating triggers, therefore
inhibition of SUMOylation has the … In recent years, novel SUMO pathway inhibitors have been …

… between both pathways. We demonstrate the relevance of the SUMO pathway as a therapeutic
target by the use of novel SUMO-activating enzyme subunit pathway inhibitors and show …

… To confirm that covalent attachment to Cys30 is the mechanism for inhibiting SUMO E1,
we conducted enzymatic assays to determine whether mutation of Cys30 could remove the …

… The following section highlights the intrinsic antiviral activity of SUMO, and focuses on
the effects of SUMO paralog overexpression or inhibition of the SUMO pathway by UBC9 …

… With establishment of PD markers for both target engagement and pathway inhibition as
well as robust tumor growth inhibition, we were encouraged to continue to optimize the …

… structure and mechanism, we divided the SUMO E3 ligases into … -like factors; the other SUMO
E3 ligases. Table 1 displays a … This makes the inhibition of SUMO E3 ligases complicated …