Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

DV Conti, BF Darst, LC Moss, EJ Saunders, X Sheng… - Nature …, 2021 - nature.com
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new
susceptibility loci and informs genetic risk prediction | Nature Genetics … 23,24 , …

[HTML][HTML] 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population

R Takata, A Takahashi, M Fujita, Y Momozawa… - Nature …, 2019 - nature.com
… by GWAS in the Japanese population 13 , with a further meta-analysis in the Japanese …
reported to be associated with poor prognosis 23 . rs4554825 was associated with expression of …

Evidence of novel susceptibility variants for prostate cancer and a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry

F Chen, RK Madduri, AA Rodriguez, BF Darst, A Chou… - European urology, 2023 - Elsevier
… We conducted a meta-analysis of ten genome-wide association studies consisting of 19
378 … Nine novel susceptibility loci for PCa were identified, of which seven were only found or …

Identification of novel susceptibility loci and genes for prostate cancer risk: a transcriptome-wide association study in over 140,000 European descendants

L Wu, J Wang, Q Cai, TB Cavazos, NC Emami, J Long… - Cancer research, 2019 - AACR
… and uncover possible causal genes at loci identified previously by GWAS (17–23). Instead of
… 90% of the individual samples, are available. The previous meta-analysis summary results …

An update on genetic predisposition for prostate cancer: Perspectives and prospects

M Abd Ellatif, B El Gamal, AO Musaam… - Cellular and Molecular …, 2023 - cellmolbiol.org
… Genome-wide association study identifies five new susceptibility loci for prostate cancer in
… A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

[HTML][HTML] Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms

NC Emami, L Kachuri, TJ Meyers, R Das… - Nature …, 2019 - nature.com
… with PrCa in a trans-ethnic meta-analysis (N = 9117). Many … of proximally located PrCa
susceptibility loci, conditional … lead PSA signal in this region 23 . Conditional associations were …

Understanding Prostate Cancer Genetic Susceptibility and Chromatin Regulation

YP Guo - 2019 - search.proquest.com
Prostate cancer (PCa) is the leading cause of new cancer … Conclusions: I identified GWAS
risk loci involved in long-range … new insights into the genetic susceptibility to prostate cancer. …

Prostate cancer risk SNP rs10993994 is a trans-eQTL for SNHG11 mediated through MSMB

M Bicak, X Wang, X Gao, X Xu… - Human molecular …, 2020 - academic.oup.com
… by meta-analysis of prostate eQTL datasets from 496 tumor … trans-eQTLs correspond with
prostate cancer risk SNPs to build … , 000 men identify 63 new prostate cancer susceptibility loci

[HTML][HTML] Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects

S Ito, X Liu, Y Ishikawa, DD Conti, N Otomo… - Nature …, 2023 - nature.com
… predictive performance 22,23 . There are two methods to … multi-ancestry meta-analysis
for PrCa and identified 171 loci … of prostate cancer susceptibility loci in a large meta-analysis

Comprehensive analysis of multiple cohort datasets deciphers the utility of germline single-nucleotide polymorphisms in prostate cancer diagnosis

W Zhang, Y Dong, O Sartor, K Zhang - Cancer Prevention Research, 2021 - AACR
… In addition to the SNPs included in the MK-61 panel, an SNP to be included in the MK-61+
panel of the MEC-AA cohort is required to meet the following two criteria: Meta-analysis P …