Renal revascularization attenuates myocardial mitochondrial damage and improves diastolic function in pigs with metabolic syndrome and renovascular hypertension

RA Farahani, S Yu, CM Ferguson, XY Zhu… - Journal of …, 2022 - Springer
… function by PTRA ameliorated myocardial mitochondrial damage and diastolic dysfunction …
that 4 weeks after technically successful renal revascularization, cardiomyocyte mitochondrial

The mitochondrial permeability transition pore: an evolving concept critical for cell life and death

G Morciano, N Naumova, P Koprowski… - Biological …, 2021 - Wiley Online Library
… an unspecific increase in permeability of the … kidney cell injury caused by mPTP opening
is provided by Bendavia, a mPTP inhibitor, which inhibits damage caused by revascularization

Physiopathology of the permeability transition pore: Molecular mechanisms in human pathology

M Bonora, S Patergnani, D Ramaccini, G Morciano… - Biomolecules, 2020 - mdpi.com
… opening of the mitochondrial permeability transition pore complex (… revascularization had
no effect on ST-segment resolution or cardiac enzymes and did not improve clinical outcome. …

Improved renal outcomes after revascularization of the stenotic renal artery in pigs by prior treatment with low-energy extracorporeal shockwave therapy

XJ Chen, X Zhang, K Jiang, JD Krier, X Zhu… - Journal of …, 2019 - journals.lww.com
… the stenotic kidney, but its ability to improve renal function and structure after revascularization
… We tested the hypothesis that a LE-SWT regimen before percutaneous transluminal renal

Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease

M Fontecha-Barriuso, AM Lopez-Diaz… - Antioxidants, 2022 - mdpi.com
… production and mitochondrial permeability transition pore (… mitochondrial biogenesis and
improved kidney function after … artery stent revascularization, it increased peripheral venous …

Renovascular disease induces mitochondrial damage in swine scattered tubular cells

AA Nargesi, XY Zhu, SM Conley… - … Physiology-Renal …, 2019 - journals.physiology.org
… of the mitochondria permeability transition pore, and exerts protective effects on the kidney
… We found that Lean STCs improved survival of injured PK1 cells, underscoring the potential …

Kidney intrinsic mechanisms as novel targets in renovascular hypertension

A Eirin, AR Chade, LO Lerman - Hypertension, 2024 - Am Heart Assoc
… A mitochondrial permeability transition pore inhibitor improves renal outcomes after
revascularization in … growth factor improves renal outcomes following revascularization. Am J …

Mitochondrial dysfunction and the AKI-to-CKD transition

M Jiang, M Bai, J Lei, Y Xie, S Xu… - … of Physiology-Renal …, 2020 - journals.physiology.org
… opening of mitochondrial permeability transition pores, loss of … or inhibit mitochondrial
permeability transition. By inhibiting … 4 wk after ischemia significantly improves renal fibrosis after

Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs

AA Nargesi, L Zhang, H Tang, KL Jordan… - Journal of …, 2019 - journals.lww.com
… are linked to poorer outcomes after renal revascularization [4] . … Increased mitochondrial
permeability facilitate water entry into … of mitochondrial fusion might have contributed to increase

The mitochondrion: A promising target for kidney disease

C Tanriover, S Copur, D Ucku, AB Cakir, NB Hasbal… - Pharmaceutics, 2023 - mdpi.com
… the mitochondria to improve kidney function and kidney treatment. … inhibitors, antioxidants,
mitochondrial permeability transition … A mitochondrial permeability transition pore (mPTP) is …