[HTML][HTML] Genome wide association study and next generation sequencing: a glimmer of light toward new possible horizons in frontotemporal dementia research
M Ciani, L Benussi, C Bonvicini… - Frontiers in Neuroscience, 2019 - frontiersin.org
… , with a strong genetic background, that causes early onset dementia. The present … genetic
linkage analysis, studies of candidate genes, Genome-Wide Association Studies (GWAS) and …
linkage analysis, studies of candidate genes, Genome-Wide Association Studies (GWAS) and …
[HTML][HTML] A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the …
, … Frontotemporal Dementia and Alzheimer's Disease … - Acta …, 2019 - Springer
… In 2017, a genome-wide association (GWA) study of Alzheimer’s disease (AD) showed that
the rare … Pro522Arg) using direct genotyping with a variety of genotyping arrays or TaqMan …
the rare … Pro522Arg) using direct genotyping with a variety of genotyping arrays or TaqMan …
Genome-Wide DNA Methylation in Early-Onset-Dementia Patients Brain Tissue and Lymphoblastoid Cell Lines
O Ramos-Campoy, A Comas-Albertí, D Hervás… - International Journal of …, 2024 - mdpi.com
… A Multiancestral Genome-Wide Exome Array Study of Alzheimer Disease, Frontotemporal
Dementia, and Progressive Supranuclear Palsy. JAMA Neurol. 2015, 72, 414–422. …
Dementia, and Progressive Supranuclear Palsy. JAMA Neurol. 2015, 72, 414–422. …
[HTML][HTML] The influence of 17q21.31 and APOE genetic ancestry on neurodegenerative disease risk
… ancestry individuals in genome-wide association studies (GWAS) … for neurodegenerative
diseases in diverse populations. … Frontotemporal dementia has been reported as being less …
diseases in diverse populations. … Frontotemporal dementia has been reported as being less …
[HTML][HTML] A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects
… these studies have focused on genome wide association studies … Pro397Ser) from Spain,
we obtained exome sequencing … The multi-ancestral origins of the PSEN1 variants suggest that …
we obtained exome sequencing … The multi-ancestral origins of the PSEN1 variants suggest that …
Dementia risk genes engage gene networks poised to tune the immune response towards chronic inflammatory states
… to Alzheimer’s disease (AD), Frontotemporal dementia (FTD) … changes, we integrated
genome-wide common genetic risk … using a cross-disorder exome array dataset that included AD…
genome-wide common genetic risk … using a cross-disorder exome array dataset that included AD…
[HTML][HTML] The role of white matter dysfunction and leukoencephalopathy/leukodystrophy genes in the aetiology of frontotemporal dementias: implications for novel …
HC Lok, JB Kwok - International Journal of Molecular Sciences, 2021 - mdpi.com
… Further, genome-wide association studies (GWAS) and next-… Indeed, as a result of the
emergence of whole-exome … is rapidly determined using specific genotyping arrays [128]. To date, …
emergence of whole-exome … is rapidly determined using specific genotyping arrays [128]. To date, …
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
SD Chen, J You, W Zhang, BS Wu, YJ Ge… - Nature Human …, 2024 - nature.com
… In the current study, we conducted a large genome-wide and exome-wide association study
… To increase the robustness of the mvGWAS results, we additionally added batch and array …
… To increase the robustness of the mvGWAS results, we additionally added batch and array …
Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease
B Wamsley, DH Geschwind - Current opinion in genetics & development, 2020 - Elsevier
… Modern application of genotyping arrays, whole exome sequencing (… and BD have uncovered
more genome wide significant common loci than in … Inheritance of frontotemporal dementia …
more genome wide significant common loci than in … Inheritance of frontotemporal dementia …
[HTML][HTML] Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease
… The AHBA includes genome-wide microarray-based expression covering the entire brain
through systematic sampling of regional tissue, where \(\sim\)60,000 probes across …
through systematic sampling of regional tissue, where \(\sim\)60,000 probes across …