… CHS3 is a TNL with additional integrated domains (LIM (Lin-… Mec-3 domain) domain and
putative DA-1 protease domain) at … CHS3 are necessary for triggering autoimmune cell death in …

… A mutant CHS3 protein with TIR‐NB‐LRR‐LIM domains modulates growth, cell death and
freezing tolerance in a temperature‐dependent manner in Arabidopsis. The Plant Journal, 63(…

… (ID) with homology to regulatory domains, which is … two cell-death regulatory modes for
CHS3/CSA1 pairs. One is mediated by ID domain on clade 1 CHS3, and the other relies on CHS3…

… cell death, but the direct mechanisms leading to such deregulation remains unclear. Here,
we found that the TIR-NBS-LRR protein … cell death in bak1-4 and bak1-4 bir3-2 mutants via …

… activity is important for TIRmediated cell death. Nicotinamide, … For example, TNL protein
CHS3 contains a LIM domain at its … mutation in csa1 can suppress bak1 bir3mediated cell death. …

… and clade 3, we made more mutations in CHS3 TIR BB-loops to assess cell death phenotype
and … We then used BN-PAGE assays to test whether BAK1 or BIR proteins modulate CHS3-…

… N- and C-termini (TIR/CC and LRR) differ in the context of each … Additionally to that,
bir2-mutants reveal elevated cell death … the cell death occurring in bir2-mutants, double-mutants …

… , Isl-1 and Mec-3 (LIM) domain at its C terminus. The gain-of-function mutant, chs3-2D, exhibiting
… (F) Quantification of Ha Noco2 conidia growth on the leaf surface of the mutant chs3-2D …

… domain swaps with several DA1 homologs, we show that the LIM-peptidase domain of the
family member CHS3/… mechanisms by which effectors modulate plant processes is enabling …

… : The S8F mutation in WRR7 inhibits the cell death induced by the WRR7 autoimmune mutant
… Plant NLRs containing a TIR domain are collectively termed TIR-domain containing NLRs (…