… features of erythroderma, blistering and skin denudation present at … Genes encoding keratin
5 and keratin 14 get expressed in … initiation and termination motifs and lead to significantly …

… and DDEB (trial was terminated due to low patient enrollment)… highly conserved 2B domain,
with the result that the keratin 5 … the potential to prevent blistering through skin stabilization in …

… -casomorphin dressing underwent reepithelization faster, ending up with a … mutations in
keratin 5 or keratin 14, highly expressed in the basal epidermis, cause the severe skin blistering …

… skin with varying severity depending on the mutation locus. Mutations in the highly conserved
region of keratin peptides … Blistering and minor nail abnormalities may also be seen. Oral …

… -phase cycling cells of the skin are first labelled with 5-bromo-2′… Helix Termination Peptide
(HTP), which is highly conserved … with a large number of blistering syndromes 57,58,59 . The …

… the amino acid residue is highly conserved across species. is … Severe generalized EBS is
an inherited blistering skin … mosaicism for a keratin 5 mutation in epidermolysis bullosa simplex …

… fibroblasts as a 290-kDa polypeptide, and three of these chains … The first one was terminated
at 12 weeks due to intrauterine … cutaneous blistering suggestive of a genetic blistering …

… A mutation in the conserved Helix termination peptide of keratin 5 in hereditary skin blistering.
Nature 356:244–246. DOI: https://doi.org/10.1038/356244a0, PMID: 1372711 Leckband …

… skin disorder which is typically identified by blistering of the … are observed to be expressing
only keratins 5 and 14, but as the … impact of the medication after cessation of 545 treatment. …

… In summary, the analysis of the different genetic models … Its variable N-termini, defined by
short isoform-specific peptides, are … In skin, the blisters are located between the dermis and the …