Evaluation of testicular toxicity upon fetal exposure to bisphenol A using an organ culture method

HJ Park, WY Lee, JT Do, C Park, H Song - Chemosphere, 2021 - Elsevier
… Here, we evaluated BPA toxicity on fetal testes using an in vitro organ culture system. Mouse
fetal testes sampled at 15.5 days post coitus were cultured in a medium containing BPA for …

Evaluation of resmethrin toxicity to neonatal testes in organ culture

HJ Park, WY Lee, M Zhang, KH Hong… - Toxicological …, 2020 - academic.oup.com
Resmethrin is a widely used pyrethroid insecticide, which causes low toxicity in mammals.
However, its toxicity in testes has not been fully investigated. Therefore, we evaluated the …

[HTML][HTML] Human amnion mesenchymal stem cells restore spermatogenesis in mice with busulfan-induced testis toxicity by inhibiting apoptosis and oxidative stress

C Qian, Q Meng, J Lu, L Zhang, H Li… - Stem cell research & …, 2020 - Springer
… for TUNEL assay and SCP3 immunofluorescence. A TUNEL … meiosis in a busulfan-induced
testis toxicity mouse model … -induced testis toxicity mouse model to evaluate testicular cell …

Mouse embryo assay for human in vitro fertilization quality control: a fresh look

N Esfandiari, A Gubista - Journal of Assisted Reproduction and Genetics, 2020 - Springer
… chemically defined BGJB medium in the presence of mouse fallopian tube cells [4]. In the …
or porcine embryos will detect embryo toxicity the same way that the mouse embryos do in a …

Reproductive and embryological toxicity of lead acetate in male mice and their offspring and mitigation effects of quercetin

P Dolati, MJ Zamiri, A Akhlaghi, Z Khodabandeh… - Journal of Trace …, 2021 - Elsevier
… and vas deferens were used for RNA extraction. Total RNA, isolated from the samples of
two mice in … (A) Sperm binding assay in mice, sperm and oocyte pronuclei stained blue; (B) …

A male germ cell assay and supporting somatic cells: its application for the detection of phase specificity of genotoxins in vitro

K Habas, MH Brinkworth… - Journal of Toxicology and …, 2020 - Taylor & Francis
… Data obtained using the STAPUT methodology revealed that the … to testicular and reproductive
toxicity in vivo. In addition, these data indicate that STAPUT isolation of rodent testicular

Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice

XX Liu, ZX Wang, F Liu - Chemosphere, 2021 - Elsevier
… barrier, and steroidogenesis production were examined in BPA-treated and control mice
testes. CCK8 assay was used to detect the effect of BPA on the proliferation of GC-1 and GC-2 …

[HTML][HTML] Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes: do we have enough knowledge?

T Svingen, CL Schwartz, AK Rosenmai, L Ramhøj… - Environmental …, 2022 - Elsevier
… and reliable testing strategies using non-animal test methods for predictive toxicology; both
to … production in the testes Neonatally Testosterone production in fetal testes can be markedly …

Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health

D Zhang, Z Zhang, Y Wu, K Fu, Y Chen, W Li, M Chu - Biomaterials, 2019 - Elsevier
… in testes) of the testes and epididymides, as well as normal testosterone levels. Female …
, were determined according to the manufacturer's protocols of the appropriate assay kits. …

[HTML][HTML] Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders

CL Schwartz, S Christiansen, AM Vinggaard… - … of Toxicology, 2019 - Springer
… in rodent toxicity studies aimed at testing compounds for … in mice at early developmental
stages, but suppress at late gestation, whereas no effects are observed in human fetal testis