A robust data-driven genomic signature for idiopathic pulmonary fibrosis with applications for translational model selection

R Ammar, P Sivakumar, G Jarai, JR Thompson - PLoS One, 2019 - journals.plos.org
… to the disease signature. Our work defines a robust genetic signature for IPF providing a …
as enables the identification of preclinical models that most closely resemble human IPF. …

Molecular signatures of idiopathic pulmonary fibrosis

IR Konigsberg, R Borie, AD Walts… - American journal of …, 2021 - atsjournals.org
… Volcano plots depicting features that are statistically significant in idiopathic pulmonary
fibrosis (IPF) lung tissue compared with control lung tissue at a false discovery rate <0.05 (blue …

[HTML][HTML] A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes

L Qiu, G Gong, W Wu, N Li, Z Li, S Chen… - … of Translational …, 2021 - ncbi.nlm.nih.gov
… Therefore, we constructed a molecular genomic signature to predict the prognosis of IPF …
the performance of the genomic signature in the validation cohort. The signature showed an …

Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis

RJ Allen, A Stockwell, JM Oldham, B Guillen-Guio… - Thorax, 2022 - thorax.bmj.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition with poor survival times. We
previously published a genome-… size estimates, we performed a genome-wide meta-analysis …

Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis

Y Wang, JK Yella, S Ghandikota… - Therapeutic …, 2020 - journals.sagepub.com
… nintedanib, for treatment of patients with idiopathic pulmonary fibrosis (IPF). However, neither
… minimal effect on IPF-specific gene signature or alter translational modifications involved in …

Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

B Ng, J Dong, G D'Agostino, S Viswanathan… - Science translational …, 2019 - science.org
Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by epithelial
injury and chronic activation of invasive fibroblasts that deposit and remodel the extracellular …

Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis

P Sivakumar, R Ammar, JR Thompson, Y Luo… - Respiratory …, 2021 - Springer
translational biomarker studies. Transcriptomic and proteomic disease signatures generated
from clinically relevant human … ” modeling can enable translational disease understanding, …

Translational research in pulmonary fibrosis

SK Mathai, DA Schwartz - Translational Research, 2019 - Elsevier
… the most common forms of pulmonary fibrosis and to review the most recent advances in
translational study in this area. This review will focus on idiopathic pulmonary fibrosis (IPF), one …

Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry

JL Todd, ML Neely, R Overton, K Durham, M Gulati… - Respiratory …, 2019 - Springer
… Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis
(IPF), non-specific interstitial pneumonia (NSIP) and organ donors. J Proteomics. 2013;85:…

Overlap of genetic risk between interstitial lung abnormalities and idiopathic pulmonary fibrosis

BD Hobbs, RK Putman, T Araki, M Nishino… - American journal of …, 2019 - atsjournals.org
… In addition, our findings provide evidence of novel genetic loci associated with ILAs, but
not with IPF. These findings provide further evidence that the DPP9, DSP, FAM13A, IVD, and …