A robust data-driven genomic signature for idiopathic pulmonary fibrosis with applications for translational model selection
R Ammar, P Sivakumar, G Jarai, JR Thompson - PLoS One, 2019 - journals.plos.org
… to the disease signature. Our work defines a robust genetic signature for IPF providing a …
as enables the identification of preclinical models that most closely resemble human IPF. …
as enables the identification of preclinical models that most closely resemble human IPF. …
Molecular signatures of idiopathic pulmonary fibrosis
IR Konigsberg, R Borie, AD Walts… - American journal of …, 2021 - atsjournals.org
… Volcano plots depicting features that are statistically significant in idiopathic pulmonary
fibrosis (IPF) lung tissue compared with control lung tissue at a false discovery rate <0.05 (blue …
fibrosis (IPF) lung tissue compared with control lung tissue at a false discovery rate <0.05 (blue …
[HTML][HTML] A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes
L Qiu, G Gong, W Wu, N Li, Z Li, S Chen… - … of Translational …, 2021 - ncbi.nlm.nih.gov
… Therefore, we constructed a molecular genomic signature to predict the prognosis of IPF …
the performance of the genomic signature in the validation cohort. The signature showed an …
the performance of the genomic signature in the validation cohort. The signature showed an …
Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition with poor survival times. We
previously published a genome-… size estimates, we performed a genome-wide meta-analysis …
previously published a genome-… size estimates, we performed a genome-wide meta-analysis …
Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis
… nintedanib, for treatment of patients with idiopathic pulmonary fibrosis (IPF). However, neither
… minimal effect on IPF-specific gene signature or alter translational modifications involved in …
… minimal effect on IPF-specific gene signature or alter translational modifications involved in …
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
… Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease characterized by epithelial
injury and chronic activation of invasive fibroblasts that deposit and remodel the extracellular …
injury and chronic activation of invasive fibroblasts that deposit and remodel the extracellular …
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis
P Sivakumar, R Ammar, JR Thompson, Y Luo… - Respiratory …, 2021 - Springer
… translational biomarker studies. Transcriptomic and proteomic disease signatures generated
from clinically relevant human … ” modeling can enable translational disease understanding, …
from clinically relevant human … ” modeling can enable translational disease understanding, …
Translational research in pulmonary fibrosis
SK Mathai, DA Schwartz - Translational Research, 2019 - Elsevier
… the most common forms of pulmonary fibrosis and to review the most recent advances in
translational study in this area. This review will focus on idiopathic pulmonary fibrosis (IPF), one …
translational study in this area. This review will focus on idiopathic pulmonary fibrosis (IPF), one …
Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry
JL Todd, ML Neely, R Overton, K Durham, M Gulati… - Respiratory …, 2019 - Springer
… Comparative proteome analysis of lung tissue from patients with idiopathic pulmonary fibrosis
(IPF), non-specific interstitial pneumonia (NSIP) and organ donors. J Proteomics. 2013;85:…
(IPF), non-specific interstitial pneumonia (NSIP) and organ donors. J Proteomics. 2013;85:…
Overlap of genetic risk between interstitial lung abnormalities and idiopathic pulmonary fibrosis
… In addition, our findings provide evidence of novel genetic loci associated with ILAs, but
not with IPF. These findings provide further evidence that the DPP9, DSP, FAM13A, IVD, and …
not with IPF. These findings provide further evidence that the DPP9, DSP, FAM13A, IVD, and …