[HTML][HTML] Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation

C Sun, T Jiao, D Merkus, DJ Duncker… - Journal of …, 2019 - Elsevier
… In the present study, Up 4 A-induced porcine coronary SMC relaxation was partially attenuated
by the H … small arteries isolated from slaughterhouse swine (~100 kg, unknown gender) is …

Adenosine and adenosine receptor-mediated action in coronary microcirculation

Y Zhang, B Wernly, X Cao, SJ Mustafa, Y Tang… - Basic Research in …, 2021 - Springer
… of hypoxia or ischemia in various tissues, adenosine together with ATP and ADP is … induced
relaxation in isolated porcine coronary arterioles or the A 2A R-induced increase in coronary

Coronary Microvascular Dysfunction in Cardiovascular Disease: Lessons from Large Animal Models

O Sorop, J van de Wouw, D Merkus… - … : From Bench to Bedside, 2020 - Springer
… the different vasoregulatory pathways as … and ADP [41] while in swine, 1h ischemia followed
by 1h reperfusion resulted in impaired relaxation to serotonin, and bradykinin in coronary

Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists

MO Dales, C Mitchell, AM Gurney, RM Drummond… - Purinergic …, 2022 - Springer
… blocking P2Y 1 and P2Y 12 receptors in pigs in vivo [15]. Thus… This shows that neither ATP
nor ADP induce vasodilatation … effect in this study on the relaxation of the rIPA evoked by ATP. …

[HTML][HTML] Mechanobiology of microvascular function and structure in health and disease: focus on the coronary circulation

MM Brandt, C Cheng, D Merkus, DJ Duncker… - Frontiers in …, 2021 - frontiersin.org
… , as in swine a residual exercise-induced vasodilation upon … In VSMCs, PGI 2 induces
relaxation via protein kinase A (PKA… transcription of many genes involved in vasoregulation (…

NO-induced vasodilation correlates directly with BP in smooth muscle-Na/Ca exchanger-1-engineered mice: elevated BP does not attenuate endothelial function

Y Wang, J Zhang, WG Wier, L Chen… - American Journal of …, 2021 - journals.physiology.org
… Previously we showed that isolated KO and control arteries … and relaxation of constricted
arteries by forskolin-induced … on membrane potential of pig coronary artery endothelial cells. …

Kynurenine relaxes arteries of normotensive women and those with preeclampsia

SA Worton, HAT Pritchard, SL Greenwood… - Circulation …, 2021 - Am Heart Assoc
… kynurenine-induced relaxation in porcine coronary arteries, 1 and … vasoregulatory axis as
the mechanism by which kynurenine … , arteries isolated from women with preeclampsia relaxed

Vascular endothelial cell biology: an update

A Krüger-Genge, A Blocki, RP Franke… - International journal of …, 2019 - mdpi.com
… It actively controls the degree of vascular relaxation and … into and out of tissues and with
local vasoregulation [59]. This is … , was isolated from the cell culture supernatant of porcine EC […

Potassium channels in the uterine vasculature: Role in healthy and complicated pregnancies

W Bresnitz, RA Lorca - International Journal of Molecular Sciences, 2022 - mdpi.com
cardiac output to the uteroplacental circulation, which equates to approximately 1 L/min or
20% of cardiac … Additionally, in non-pregnant guinea pigs, ACh-dependent UtA relaxation was …

[HTML][HTML] The calcium signaling mechanisms in arterial smooth muscle and endothelial cells

M Ottolini, SK Sonkusare - Comprehensive Physiology, 2021 - ncbi.nlm.nih.gov
The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …