A novel and sensitive DNA methylation marker for the urine-based liquid biopsies to detect bladder cancer

L Deng, H Chao, H Deng, Z Yu, R Zhao, L Huang… - BMC cancer, 2022 - Springer
… In recent years, a variety of novel biomarkers have been screened and identified in urine
sediments for BC detection through wide-ranging technologies including MassARRAY, …

DNA-methylation-based detection of urological cancer in urine: overview of biomarkers and considerations on biomarker design, source of DNA, and detection …

LK Larsen, GE Lind, P Guldberg, C Dahl - International journal of …, 2019 - mdpi.com
… The procedure for collection of urine sediments is simple and … co-sedimentation of normal
cells and the presence of crystals and … A recent study showed that the sensitivity for detection of …

Comparative analysis of urine fractions for optimal bladder cancer detection using DNA methylation markers

AE Hentschel, JA Nieuwenhuijzen, J Bosschieter… - Cancers, 2020 - mdpi.com
… compared three urine fractions for BC detection through DNA methylation analysis. … methylation
levels in each of the urine fractions and the matched tumor tissues for most of our markers

Improved urine DNA methylation panel for early bladder cancer detection

Q Fang, X Zhang, Q Nie, J Hu, S Zhou, C Wang - BMC cancer, 2022 - Springer
… that methylation changes found in urine sediments resemble those … DNA methylation panel
for early BC detection in clinical practise. We composed an improved urine DNA methylation

A noninvasive urine-based methylation biomarker panel to detect bladder cancer and discriminate cancer grade

T Hermanns, AJ Savio, E Olkhov-Mitsel, A Mari… - … Oncology: Seminars and …, 2020 - Elsevier
Urinary cell sediment DNA was evaluated using … , methylation markers have also been
investigated. The Bladder EpiCheck, a novel urine assay using 15 proprietary DNA methylation

High Detection Rate for Non–Muscle-Invasive Bladder Cancer Using an Approved DNA Methylation Signature Test

D Steinbach, M Kaufmann, J Hippe, M Gajda… - Clinical Genitourinary …, 2020 - Elsevier
… combination of DNA methylation detection and urine cytology … for BCa detection by 10%
(ASTN1/ITGA4/SOX17 methylation … the detection of BCa in tumor tissue and urine sediment from …

A novel ultra-sensitive method for the detection of FGFR3 mutations in urine of bladder cancer patients – Design of the Urodiag® PCR kit for surveillance of patients …

JP Roperch, C Hennion - BMC Medical Genetics, 2020 - Springer
… We have recently developed a highly accurate urine-based test, named Urodiag®, associating
FGFR3 mutation and DNA methylation assays for recurrence surveillance in patients with …

Urinary markers for bladder cancer diagnosis: A review of current status and future challenges

E Tomiyama, K Fujita, M Hashimoto… - … Journal of Urology, 2024 - Wiley Online Library
… Therefore, the detection of MCM5 in urine sediments is … FGFR3 mutations as a sensitive/specific
urinary assay for diagnosis and … BladMetrix: a novel urine DNA methylation test with high …

High-yield methylation markers for stool-based detection of colorectal cancer

X Liu, J Wen, C Li, H Wang, J Wang, H Zou - Digestive Diseases and …, 2020 - Springer
… Stool DNA testing is a novel CRC screening tool that detects … for discrepancies in marker
performance among studies. In … of reported DNA methylation markers for the detection of …

Current and emerging bladder cancer biomarkers with an emphasis on urine biomarkers

A Lopez-Beltran, L Cheng, T Gevaert… - Expert review of …, 2020 - Taylor & Francis
… is a novel urine assay that uses 15 proprietary DNA methylation biomarkers … group of Su
et al [Citation42] recently analyzed DNA methylation levels of six markers in 368 urine sediment