Simultaneous determination of celecoxib, dezocine and dexmedetomidine in beagle plasma using UPLC-MS/MS method and the application in pharmacokinetics

J Hu, X Su, HL Si, RX Song, F Zhang… - Drug Design …, 2021 - Taylor & Francis
… All of them met the acceptance standard of biological analysis method recommended by …
determination of CEL, DEX and DEX, and has been successfully applied to the study of …

Investigational drugs for the treatment of cancer cachexia: a focus on phase I and phase II clinical trials

A Molfino, MI Amabile, A Giorgi, M Monti… - Expert opinion on …, 2019 - Taylor & Francis
… selective cyclooxygenase-2 inhibitor celecoxib) in a population of … tested in phase I/II
uncontrolled trial combined with megestrol … mechanisms activated and biologically involved. In …

[PDF][PDF] Efficacy and Safety of Low Dose Celecoxib with Chemoradiation in Locally advanced Head and Neck Squamous Cell Carcinoma

RT Kumar - 2020 - repository-tnmgrmu.ac.in
combination with celecoxib. … determine whether celecoxib might be useful for this latter
condition. However, during molecular studies in the laboratory, it became apparent that celecoxib

[HTML][HTML] COX2 inhibition in the treatment of COVID-19: Review of literature to propose repositioning of celecoxib for randomized controlled studies

S Baghaki, CE Yalcin, HS Baghaki, SY Aydin… - International Journal of …, 2020 - Elsevier
the best alternatives until a definitive treatment is found (ie vaccine- and/or drug-based). Until
definitive treatments are determined… patients and deaths, together with stretched healthcare …

Celecoxib repurposing in cancer therapy: molecular mechanisms and nanomedicine-based delivery technologies

AF Khafaga, RN Shamma, A Abdeen, AM Barakat… - …, 2021 - Future Medicine
… physicochemical challenges and biological barriers of CXB … and Phase I clinical trials and
moving directly into Phase II … clinical study evaluating the combined use of Celecoxib with …

… -deficient or microsatellite instability-high, locally advanced, colorectal cancer (PICC): a single-centre, parallel-group, non-comparative, randomised, phase 2 trial

H Hu, L Kang, J Zhang, Z Wu, H Wang… - The lancet …, 2022 - thelancet.com
… whether neoadjuvant toripalimab with or without celecoxib … colorectal cancers, we found the
best estimates of the proportion of … , toripalimab in combination with celecoxib compared with …

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

P Rodrigues, H Bangali, A Hammoud, YF Mustafa… - Medical Oncology, 2024 - Springer
… These include determining the optimal dose and duration of … chemotherapy drugs, such
as biological alkylating agents, anti-… Vandetanib and Celecoxib combination therapy was first …

Intra-articular multifunctional celecoxib loaded hyaluronan nanocapsules for the suppression of inflammation in an osteoarthritic rat model

RI El-Gogary, MA Khattab, H Abd-Allah - International journal of …, 2020 - Elsevier
… formulation aimed to combine the beneficial … the optimized hyaluronan nanocapsules
formulation showed the superiority of the prepared celecoxib nanocapsules compared to celecoxib

Metronomic therapy in pediatric oncology: a snapshot

R Pramanik, S Bakhshi - Pediatric Blood & Cancer, 2019 - Wiley Online Library
… or in combination with other nonchemotherapeutic agents such as celecoxib and thalidomide…
Future preclinical studies should focus on determination of optimum biological dosage and …

New 1, 2, 4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory …

WAA Fadaly, YAMM Elshaier, EHM Hassanein… - Bioorganic …, 2020 - Elsevier
… ] and celecoxib-NO hybrids [46], [47], [48] we aimed to study the effect of combination of the
… The target derivatives 16a-f and 19a-f had some modifications in the structure of celecoxib (1…