… whether neoadjuvant toripalimab with or without celecoxib … colorectal cancers, we found the
best estimates of the proportion of … , toripalimab in combination with celecoxib compared with …

… the optimal biological dose (OBD) based on safety and efficacy. BOIN designs provide a
complete suite for dose finding in early phase trials… of a combination therapy to determine either …

… dose for treating patients. For these novel therapies, the objective of dose-finding trials is to
identify the optimal biologic dose (OBD) … to the methotrexate plus erlotinib plus celecoxib trial. …

… These include determining the optimal dose and duration of … chemotherapy drugs, such
as biological alkylating agents, anti-… Vandetanib and Celecoxib combination therapy was first …

… the efficacy of celecoxib is enhanced when combined with … short-term use of celecoxib offered
the best option for minimizing … , Infection biology group involved in this study. RISystem AG, …

… formulation aimed to combine the beneficial … the optimized hyaluronan nanocapsules
formulation showed the superiority of the prepared celecoxib nanocapsules compared to celecoxib …

… an initial celecoxib of 6 mg kg −1 with a maintenance dose celecoxib 3 … This type of nonlinear
relationship with a maximum effect is … benefits of combination therapy (eg, celecoxib and …

… or in combination with other nonchemotherapeutic agents such as celecoxib and thalidomide…
Future preclinical studies should focus on determination of optimum biological dosage and …

… The analgesic celecoxib has long been shown to have … encouraging results in combination
with low-dose temozolomide. The … We used the best overall response, ie, the best response …

… Bayesian modelling to identify the optimal biological dose of methotrexate in combination with
erlotinib and celecoxib on the … A dose of 9 mg/m2 of methotrexate weekly was identified as …