[HTML][HTML] Fruquintinib with gefitinib as first-line therapy in patients carrying EGFR mutations with advanced non-small cell lung cancer: a single-arm, phase II study

S Lu, JY Zhou, XM Niu, JY Zhou, H Jian… - … Lung Cancer …, 2021 - ncbi.nlm.nih.gov
… This phase II trial assessed efficacy and safety of fruquintinib in combination with gefitinib,
in patients with advanced non-small cell lung cancer (NSCLC). …

… gefitinib as first-line therapy for Chinese patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer (FURLONG): a multicentre …

Y Shi, G Chen, X Wang, Y Liu, L Wu, Y Hao… - The Lancet …, 2022 - thelancet.com
… This study shows that furmonertinib was superior to gefitinib in terms of progression-free
survival as first-line treatment for Chinese patients with EGFR mutation-positive NSCLC. This …

[HTML][HTML] A randomized phase 2 study of gefitinib with or without pemetrexed as first-line treatment in nonsquamous NSCLC with EGFR mutation: final overall survival …

JCH Yang, Y Cheng, H Murakami, PC Yang… - Journal of Thoracic …, 2020 - Elsevier
… as first-line therapy significantly improved PFS and led to a trend for prolonged OS compared
with gefitinib … growth factor receptor tyrosine kinase inhibitors in nonsmall cell lung cancer

Combination of metformin and gefitinib as first-line therapy for nondiabetic advanced NSCLC patients with EGFR mutations: a randomized, double-blind phase II trial

L Li, L Jiang, Y Wang, Y Zhao, XJ Zhang, G Wu… - Clinical cancer …, 2019 - AACR
… who have diabetes with nonsmall cell lung cancer (NSCLC) to EGFR tyrosine kinase
inhibitors (TKIs). We therefore examined its effects in combination with gefitinib in patients without …

[HTML][HTML] Gefitinib as neoadjuvant therapy for resectable stage II-IIIA nonsmall cell lung cancer: A phase II study

Y Zhang, F Fu, H Hu, S Wang, Y Li, H Hu… - The Journal of Thoracic …, 2021 - Elsevier
… This phase II trial examines the efficacy of neoadjuvant gefitinib in patients with clinically …
EGFR-TKIs has been used as first-line therapies in advanced EGFR-mutant NSCLC, but there …

[HTML][HTML] Apatinib plus gefitinib as first-line treatment in advanced EGFR-mutant NSCLC: the phase III ACTIVE study (CTONG1706)

H Zhao, W Yao, X Min, K Gu, G Yu, Z Zhang… - Journal of thoracic …, 2021 - Elsevier
… ACTIVE is the first phase 3 study conducted in the People’s Republic of China … factor receptor
2 tyrosine kinase inhibitor, plus gefitinib as first-line therapy in … Nonsmall cell lung cancer

The ACTIVE study protocol: apatinib or placebo plus gefitinib as first-line treatment for patients with EGFR-mutant advanced non-small cell lung cancer (CTONG1706)

Z Zhang, F Luo, Y Zhang, Y Ma, S Hong, Y Yang… - Cancer …, 2019 - Springer
… A single-arm phase II trial, the BELIEF study, demonstrated a 1-year PFS of 55.6%, with a …
phase II study (JO25567) evaluated bevacizumab plus erlotinib in patients with stage IIIB/IV or …

Efficacy and safety of gefitinib as third-line treatment in NSCLC patients with activating EGFR mutations treated with first-line gefitinib followed by second-line …

Y Song, YL Wu, LJ Cao, JH Chen, ZY Ma… - American Journal of …, 2019 - journals.lww.com
… standard care for advanced nonsmall cell lung cancer (NSCLC… Recently, a similar phase II
trial that demonstrated first-line … re-challenge with gefitinib after first-line treatment with EGFR-…

… survival in a randomized study comparing dacomitinib with gefitinib as first-line treatment in patients with advanced non-small-cell lung cancer and EGFR-activating …

TS Mok, Y Cheng, X Zhou, KH Lee, K Nakagawa… - Drugs, 2021 - Springer
… In conclusion, the OS benefit from first-line treatment with dacomitinib versus gefitinib
was maintained after extended follow-up in patients with advanced NSCLC with EGFR-activating …

AENEAS: A randomized phase III trial of aumolertinib versus gefitinib as first-line therapy for locally advanced or metastaticnon–small-cell lung cancer with EGFR exon …

S Lu, X Dong, H Jian, J Chen, G Chen… - Journal of Clinical …, 2022 - ascopubs.org
… This double-blind phase III trial evaluated the efficacy and safety of … with gefitinib as a
first-line treatment for locally advanced or metastatic EGFR-mutated nonsmall-cell lung cancer (…