… In addition, about half of rats exhibit shock-resistant alcohol intake when 1 in 8 responses is
paired with footshock… Thus, identification of high-drinking rats at the early stages of voluntary …

… the treatment of alcohol use disorder (AUD). While no single … These preclinical models are
also crucial for identifying new … deprivation, Wistar rats not only increased alcohol intake and …

… Human preclinical and clinical studies are needed to determine … In studies using animal
models, there was evidence that … protocol, rats were trained to self-administer oral alcohol in …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

… This review focuses primarily on preclinical animal studies … alcohol drinking in adolescent
female rats, but decreased … such as the Alcohol Use Disorders Identification Test (AUDIT) self-…

… In summary, additional in vivo research is required to determine the importance of glutamate
and … Because the taste of alcohol is aversive to most animals, heterogeneous stock rats, eg, …

… use the term alcohol use disorder in this Seminar to denote a pattern of compulsive heavy
alcohol use and a loss of control over alcohol intake… mediate risk have been difficult to identify. …

… the effects of systemically administered baclofen on alcohol drinking in rats identified as …
of habituation to the animal facility followed by two weeks of food restriction, rats (n = 48) …

… targets other than cannabinoid receptors have been identified. In particular, CBD is a partial
… is effective in animal models such as the postdependent state, in which rats drink ethanol for …

… a substance use disorder diagnosis, and interestingly the percent of rats … alcohol intake in
rats, and also lessened cue-induced … , pharmaceutical companies can identify more successful …