… Numbers to be randomised (sample size) The total number of participants needed to evaluate
efficacy, 13,060 participants, satisfies the needed sample size calculated to evaluate safety…

Background Elevated proinflammatory cytokines are associated with greater COVID-19 severity.
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …

… Previous clinical trials have shown the safety and efficacy of the AZD1222 (ChAdOx1 nCoV-…
of a pivotal phase 3, double-blind, placebo-controlled trial that assessed the safety, efficacy, …

… in phase 1/2 trials, and provided a good humoral response against SARS-CoV-2. We
present the interim efficacy and safety results of a phase 3 clinical trial of CoronaVac in Turkey. …

… We undertook a second pivotal phase 3 study to confirm the efficacy and safety of three doses
of oral lasmiditan (200 mg, 100 mg and 50 mg) versus placebo for the acute treatment of a …

… of a multicentre, double-blind, randomised, placebo-controlled phase 3 trial at 49 centres
in India. Healthy participants aged at least 12 years were enrolled and randomly assigned (1:1) …

… In this article, we report the efficacy of … the phase III trial collected during a 3-month period
after the second injection in 18–59 year-old subjects in Indonesia. This data set and trial results …

… ” retrieved 44 articles, with no phase 3 clinical trials related to any of the remaining CGRP …
Added value of this study We provide results from the first phase 3 clinical trial of the ODT …

… This study evaluates the efficacy and safety of baricitinib in combination with standard of …
Added value of this study This was the first phase 3 study to evaluate baricitinib in addition to …

… We aimed to compare the efficacy of interferon beta-1a in combination with remdesivir … We
did a double-blind, randomised, placebo-controlled trial at 63 hospitals across five countries (…