… of methionine restriction on hallmarks of cancer in vitro and in vivo. The review highlights the
role of … Given that polyamine synthesis is dependent upon methionine, MR may be a novel …

… The significance of MTA as a PRMT5 inhibitor becomes evident when we consider the
rate … Most notably, when methionine-dependent cancer cells are continuously cultured in …

… deprivation has been demonstrated to activate autophagy in cancer cells [108,109], the
role of autophagy in the antitumor effects of methionine restriction is poorly understood. …

… Methionine-dependency reflects the crucial role of one-carbon metabolism (1-CM) in … with
methionine dependency in various cancer cells, including primary ductal carcinoma, gliomas, …

… for normal growth and development, and functions as an … rats were dependent on the
content of dietary methionine [44]. … of cancer growth is related to a decrease in oxidative stress. …

… role of methionine metabolism in tumorigenic mechanisms, which we discuss later in this
Review… cancer-specific auxotrophic methionine dependency discussed above (see the “Dietary …

… and general hallmark of cancer. Methionine addiction is due to excess use of methionine for
… The importance of methionine addiction of cancer is becoming widely recognized (9, 23). …

… cancer cells make normal or large amount of methionine, but still usually require an exogenous
source of methionine … The methionine addiction of cancer is known as the Hoffman effect. …

… most cancer cells, but not normal cells, are hyper dependent … to methionine, and diets
restricted for methionine increase … Methionine’s impact on physiology goes beyond its role in …

… restriction of the essential amino acid methionine—the reduction of which has anti-ageing
and anti-obesogenic properties—influences cancer … has a myriad of functions as a result of its …