… their utility for basic science and translational value for SUD. The … drug reward and identify
potential therapeutic interventions for SUD. … to our understanding of drug abuse and addiction. …

… pharmacology has a long and rich history in addiction science, … a novel translational
meta-analytic approach to test whether … Monte Carlo method was used to account for predictor …

… AOPs can be potentially applied to more … and translational research. Genomic and
pharmacogenomic screening have found use in clinical trial enrollment, yet even the predictive value …

… Given the wide array of potential pharmacological targets … the clinic to aid our translational
understanding in a disease … channel antagonists and drugs with abuse potential. Although not …

… any bias and quantify the predictive power of the model. This … QSP/QST is a holistic approach
to translational medicine … an illustration of the potential of the QSP approach and role of …

… prediction is important for determining the abuse potential of … , whereas MOR antagonists
provide potential for reversing opioid … affinity of the new drug at the predicted biological targets. …

… the potential of a quantitative systems pharmacology (QSP) … QSP as “an approach to
translational medicine that combines … for substance abuse disorders such as nicotine …

… sources of complexity with potentially degraded predictive power 81 . Furthermore, it must
… of degraded predictive power in preclinical oncology models. Finally, reverse translational …

… This review presents the abuse potential and unique pharmacology of fentanyl and elucidates
its potential … However, translational studies and clinical trials still need to be conducted. …

… [points to] the need to carefully evaluate the predictive power of such animal models.” …
because it had not understood the quantitative power of predictive validity. It sometimes embraced …