Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease

P Anggreini, H Kuncoro… - Molecular medicine …, 2023 - spandidos-publications.com
… to summarize the role of AMPK and SIRT1 in NAFLD, … of AMPK and SIRT1 activators on
NAFLD. Articles were obtained from the PubMed database identified using the key words ‘SIRT1

Pharmacological perspectives and clinical benefits of SIRT1 and AMPK activators and inhibitors in inflammatory and oxidative stress in the liver

L Njeka Wojnarová - 2022 - dspace.cuni.cz
… (SIRT1) and AMP-activated protein kinase (AMPK), can effectively attenuate acute liver injury.
Although SIRT1 and AMPK … evidence for a mutual SIRT1/AMPK signaling mechanism and …

SIRT1 antagonizes oxidative stress in diabetic vascular complication

T Meng, W Qin, B Liu - Frontiers in endocrinology, 2020 - frontiersin.org
… Importantly, AMPK and SIRT1 both regulate each other and have similar effects on various
cellular processes such as cell metabolism, DNA repair, mitochondrial function, and cell …

Epigenetic Changes in Aging: The Contribution of SIRT1 to Longevity

DK Alves-Fernandes, MG Jasiulionis - Cellular and Molecular Aspects of …, 2024 - Springer
… turn, AMPK promotes NAD+ synthesis, which is required to SIRT1 activity [123]. The activation
of AMPK enhances SIRT1 … 1α (PGC1α), another target of SIRT1 [124]. PGC1α serves as a …

Inverse correlation between the expression of AMPK/SIRT1 and NAMPT in psoriatic skin: A pilot study

F D'Amico, G Costantino, L Salvatorelli… - Advances in Medical …, 2022 - Elsevier
… Given the involvement of SIRT1 in inhibiting proliferation and … dysregulatory aspects of SIRT1,
NAMPT and AMPK in psoriasis… , the protein expression of SIRT1, AMPK (and pAMPK) and …

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

X Yang, Q Liu, Y Li, Q Tang, T Wu, L Chen, S Pu… - Adipocyte, 2020 - Taylor & Francis
… activated protein kinase (AMPK) – silent information regulator 1 (Sirt1) – peroxisome proliferator…
that Cana increased AMPK phosphorylation and the expression of Sirt1 and Pgc-1α. The …

Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway

YK Cui, YX Hong, WY Wu, WM Han, Y Wu, C Wu… - European Journal of …, 2022 - Elsevier
… hypertrophy via Sirt1-mediated activation of AMPK/PGC-… Sirt1/AMPK participates in
antagonization of acacetin against cardiomyocyte hypertrophy. AMP-activated protein kinase (AMPK) …

[HTML][HTML] Short-term moderate caloric restriction in a high-fat diet alleviates obesity via AMPK/SIRT1 signaling in white adipocytes and liver

S Zhang, S Sun, X Wei, M Zhang, Y Chen… - Food & nutrition …, 2022 - ncbi.nlm.nih.gov
AMPK and SIRT1 are long-term partners (31). They have similar effects on diverse
processes, such as cellular fuel metabolism, inflammation, and mitochondrial function. …

Advanced glycation end products induced mitochondrial dysfunction of chondrocytes through repression of ampkα-SIRT1-PGC-1α pathway

Q Yang, Y Shi, T Jin, B Duan, S Wu - Pharmacology, 2022 - karger.com
… AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and its downstream target … of
AMPKα/SIRT1/PGC-1α. Methods: We knocked down or overexpressed AMPKα, SIRT1, and PGC-…

The mixed blessing of AMPK signaling in Cancer treatments

M Sadria, D Seo, AT Layton - BMC cancer, 2022 - Springer
SIRT1 inhibitor at a dosage that reduces SIRT1 bioavailability to 10% of its baseline. We then
examined the resulting AMPK … indirect AMPK inhibition via the inhibition of SIRT1, which is …