Anti‐fibrotic mechanisms of angiotensin AT2receptor stimulation

C Sumners, AA Peluso, AH Haugaard… - Acta …, 2019 - Wiley Online Library
… , but it was demonstrated that the AT 2 R-mediated increase in PP2A activity in neurons …
effect of AT 2 R stimulation in the absence or presence of an AT 1 R blocker on hypertensive

The renin-angiotensin system in hypertension, a constantly renewing classic: focus on the angiotensin AT2-receptor

KB Assersen, C Sumners, UM Steckelings - Canadian Journal of …, 2020 - Elsevier
… the angiotensin AT 2 -receptor (AT 2 R), which is one of the “counter-regulatory” receptors
within … that an increase in AT 2 R-expression, which in normal pregnancy protects women from …

GABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses

AG Dupont, L Légat - Hypertension Research, 2020 - nature.com
… We speculate that AT 2 receptor stimulation might increase the GABA levels … receptor
antagonists. This idea is in line with findings demonstrating that activation of the AT 2 receptors in …

Mas receptor activation contributes to the improvement of nitric oxide bioavailability and vascular remodeling during chronic AT1R (angiotensin type-1 receptor) …

C Savoia, E Arrabito, R Parente, C Nicoletti… - …, 2020 - Am Heart Assoc
hypertension. In particular, major findings from the present study are the following: (1) chronic
AT1R blockade enhances expression and activation … is also enhanced in AT2R knockout …

Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia …

O Ozhan, H Parlakpinar, A Acet - Fundamental & Clinical …, 2021 - Wiley Online Library
increases vasodilation by blockade of AT 1 receptors and enhancing AT 2 receptors activation
These two drugs are used in the treatment of hypertension, congestive heart failure, and …

[HTML][HTML] Effects of angiotensin-(1-7) and angiotensin II on acetylcholine-induced vascular relaxation in spontaneously hypertensive rats

F Zhang, Y Xu, Y Pan, S Sun, A Chen, P Li… - … medicine and cellular …, 2019 - hindawi.com
… In the present study, we found that Ang-(1-7) enhanced ACh-… blocked by pretreatment with
Mas receptor antagonist A-779. … to antagonists against not only Mas but also AT1, AT2, and …

[HTML][HTML] Role of the central renin‑angiotensin system in hypertension

C Su, J Xue, C Ye, A Chen - … journal of molecular …, 2021 - spandidos-publications.com
AT1 in the PVN increases CSAR and stimulates the nervous system, which is involved in
renovascular hypertension… insulin signaling through AT-1 and AT-2 receptors, induces insulin …

Angiotensin III/AT2 Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension

JL Zhuo, XC Li - Journal of the American Heart Association, 2019 - Am Heart Assoc
… , 13 , 17 It is, therefore, attractive to propose that pharmacological approaches may be
used to either increases angiotensin III generation by targeting aminopeptidase A or …

[HTML][HTML] … , AT2 and Mas Receptors Responsible for Blood Pressure Control in the Paraventricular Nucleus of Hypothalamus in Conscious Spontaneously Hypertensive …

K Mińczuk, E Schlicker, B Malinowska - Cells, 2022 - mdpi.com
Increases in blood pressure in response to Ang II were strongly inhibited by antagonists of
AT 1 (losartan), AT 2 (… the pressor effects of Ang 1–7 and the involvement of AT 2 Rs in the …

[HTML][HTML] The AT1/AT2 Receptor Equilibrium Is a Cornerstone of the Regulation of the Renin Angiotensin System beyond the Cardiovascular System

M Colin, C Delaitre, S Foulquier, F Dupuis - Molecules, 2023 - mdpi.com
activation of the AT 2 receptor promotes the activation of an anti-inflammatory axis [94,95]. …
In AT 1A receptor KO mice, there was an absence of hypertensive response following Ang II …