ATM protein kinase: old and new implications in neuronal pathways and brain circuitry

L Pizzamiglio, E Focchi, F Antonucci - Cells, 2020 - mdpi.com
… of vesicles playing complementary roles: ATM with excitatory (VGLUT1+) vesicles and ATR
with inhibitory … and in controlling neuronal function and behaviour. Considering the crucial …

ATM rules neurodevelopment and glutamatergic transmission in the hippocampus but not in the cortex

E Focchi, C Cambria, L Pizzamiglio, L Murru… - Cell Death & …, 2022 - nature.com
inhibitor Fluoxetine (Fluox), we demonstrate that ATM … as cytoplasmic vesicles membrane
and transport vesicles membrane (… not experience any hyperexcitability behaviour after kainate …

ATR regulates neuronal activity by modulating presynaptic firing

M Kirtay, J Sell, C Marx, H Haselmann… - Nature …, 2021 - nature.com
… specific ATR deletion in inhibitory and excitatory postmitotic … , whether ATR directly modulates
presynaptic vesicle behaviors or … Although the expression of ATR and ATM seemed to be …

New views of the DNA repair protein ataxia–telangiectasia mutated in central neurons: Contribution in synaptic dysfunctions of neurodevelopmental and …

S Briguglio, C Cambria, E Albizzati, E Marcello… - Cells, 2023 - mdpi.com
… the great importance of ATM in neuronal functions and in synaptic vesicle recycling [29]. A
ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle

ATM loss disrupts the autophagy-lysosomal pathway

A Cheng, KH Tse, HM Chow, Y Gan, X Song, F Ma… - Autophagy, 2021 - Taylor & Francis
… synaptic vesicle binding proteins. Extending this observation, we found that ATM inhibition
… affected other key proteins, we assessed the behavior of SLC2A4, a glucose transporter […

The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

M Reichlmeir, RP Duecker, H Roehrich, J Key… - bioRxiv, 2024 - biorxiv.org
… and phosphorylome - both direct ATM/ATR-phosphopeptides and … with HALT phosphatase
inhibitors (Thermo Fisher Scientific) … kinase targets of ATM, we performed two complementary

[PDF][PDF] DNA damage and transcriptional regulation in ipsC-derived neurons from Ataxia telangiectasia patients

D Lecis, KH Chrzanowska, D Delia - core.ac.uk
… regulate endocytosis of synaptic vesicles, as opposite to ATR which associates with inhibitory
ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

A Corti, R Sota, M Dugo, RA Calogero, B Terragni… - Scientific Reports, 2019 - nature.com
ATM was shown to segregate with and regulate endocytosis of synaptic vesicles, as opposite
to ATR which associates with inhibitory … transcriptional rescue behavior between WT and …

In Cerebellar Atrophy of 12-Month-Old ATM-Null Mice, Transcriptome Upregulations Concern Most Neurotransmission and Neuropeptide Pathways, While …

M Reichlmeir, J Canet-Pons, G Koepf, W Nurieva… - Cells, 2023 - mdpi.com
… inositol lipids, while ATM and its homolog ATR were reported to … excitation, while ATR was
implicated in a complementary … of synaptic vesicles not only for excitatory but also for inhibitory

Versatility of the Mec1ATM/ATR signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses

I Corcoles-Saez, K Dong, RS Cha - Current genetics, 2019 - Springer
… of the human ATM and MEC1, the budding yeast ATM/ATR, were shown … Further analyses
unveiled that ATM and Mec1 promote … the key findings and discuss ATM/ATR as a multifaceted …