… ATP, in addition to its classical role as the energy currency of living cells, is an important …
Broadly expressed, the plasma membrane ATP release channel PANX1 has been implicated in …

… channel and its function as an ATP release channel [57]. The most direct evidence that
pannexin-1 is an ATP-permeable channel … The opening and activation of pannexin-1 channels …

… of the Peizo1 channel can induce ATP release and regulate hDP-MSC migration, as we
have shown here for chemical activation of the Pieoz1 channel. Moreover, both ATP-induced …

… , in the central nervous system (CNS) ATP appears to be primarily a slow transmitter/…
effects of ATP arise as a result of its vesicular/nonvesicular release from astrocytes. ATP acts …

… Cell damage results in ATP release to the extracellular space, and this can signal through
a range of P2XRs to initiate pain sensation. In addition, ATP is transported into secretory …

… For example, taking advantage of the permeability to Ca 2+ ions during ATP-gated P2X
channel opening, versatile tools were developed by fusing the genetically encoded Ca 2+ …

… ATP release from astrocytes, activation of adenosine receptors in the axon initial segment
and the nodes of Ranvier, increased cyclic AMP concentration, activation of HCN2 channels, …

… channels changes to become inhibitory, closing the channels. As soon as the release channels
… level that stimulates the opening of the release channels. A new cycle can then begin. …

… supports that ATP is released from cells through pannexins, a family of heptameric large
pore-forming channels. However, the activation mechanisms that trigger ATP release by …

… and release of the proinflammatory cytokines IL-1β and IL-18. In this study, we show that
ATP … We find that antagonists of PLA 2 and Cl − channels abolish P2X7 receptor–mediated …