… in cancer cells, suggesting the association of HIF-1-mediated … to cancer cell-specific gene
mutations or an aberrant gene … of isocitrate dehydrogenase 3 (IDH3), IDH3α [37], or mutations …

… on aberrant IDH1, IDH2, and IDH3 expressions in cancers. … IDH3α-mediated
promotion of tumor growth and IDH3α silencing delays tumorigenesis by suppressing HIF-1-mediated …

… –induced extramitochondrial IDH3α, we defined the IDH3α interactome using IP-MS studies
in patient-derived GICs, expressing a scrambled or an IDH3α-… Aberrant expression of IDH3α …

… 124 of the human IDH3α polypeptide, IDH3α can localize to … resulting in aberrant amino acid
metabolism and acid buildup, … IDHs promote tumor development, while reduced expression …

… to promote cell transformation. The different consequences of IDH3α aberrant expression
for … by the diverse metabolic requirements of each tissue during malignant transformation. …

… dehydrogenases in metabolism, provide a current overview of cancer-… in microvessel density
and tumor growth, suggesting an … IDH3α promotes the upregulation of the expression of …

… not clear whether the aberrant expression of IDH3α is related to … of IDH3α expression on
tumor growth after cisplatin treatment. … Overall, high expression of IDH3α promoted metabolic …

… aberrant metabolite found in tumor cells, exerting a pivotal influence on … in cancer
immunotherapy. This review delves into the metabolism, biological functions, and impacts on the …

… a metabolic shift towards aerobic glycolysis, even under normoxic conditions (Warburg effect)
[31]. This metabolic switch promotes tumor growth and … to aberrant angiogenesis in cancer …

… promoting G 1 –S transition and cell growth. However, previous study reported that IDH3α
induced HIF-1–mediated metabolic … Because both IDH3α and IDH3β are the subunits of IDH3, …