Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K+ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions

L Castro, M Noelia, M Vidal-Jorge… - Journal of …, 2019 - liebertpub.com
K ATP channels expressed in the mammalian brain have the … not Kir6.2, to confirm that
our antibody was not cross-reactingaberrant regulation, or blockade of the different pore-forming

ATP-Sensitive potassium channel subunits in neuroinflammation: novel drug targets in neurodegenerative disorders

F Maqoud, R Scala, M Hoxha… - CNS & Neurological …, 2022 - ingentaconnect.com
KATP channels are hetero-multimeric complexes of … the pore-forming subunits (Kir6.1 and
Kir6.2) likewise expressed in … mouse hippocampus; the hippocampal long-term potentiation …

[HTML][HTML] The Role of Neuronal ATP-Sensitive Potassium Channels in Learning and Memory

S Yahil - 2021 - search.proquest.com
… in the hippocampus was inhibited by KATP channel activation, … Little is known about KATP
channels in glia, though it is well-… expressed widely, with the dominant pore-forming subunit

[HTML][HTML] Kir6. 2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation

N Song, Y Fang, H Zhu, J Liu, S Jiang, S Sun, R Xu… - Redox Biology, 2021 - Elsevier
Kir6.2, a KATP channel pore-forming subunit, is mainly … Our previous study has found that
aberrantly-expressed kir6.2 in A1 … cerebral cortex, substantia nigra, caudate and hippocampus. …

[HTML][HTML] Unraveling the Role of Inwardly Rectifying Potassium Channels in the Hippocampus of an Aβ(1–42)-Infused Rat Model of Alzheimer's Disease

E Akyuz, C Villa, M Beker, B Elibol - Biomedicines, 2020 - mdpi.com
channels consist of four pore-forming Kir6 subunits (Kir6.1 … In neurons, the K ATP channels
are mainly constituted by the … reactive astrocytes from a triple transgenic mouse model of AD (…

Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy

E Akyuz, B Koklu, A Uner… - Journal of …, 2022 - Wiley Online Library
… to the modulation of Kir4.1 expression in reactive astrocytes by Wnt/β-… activation of K ATP
channels in hippocampal neurons. … consists of TM1 and TM2, extracellular pore-forming region …

ATP-sensitive potassium channels: A double-edged sword in neurodegenerative diseases

J Lv, X Xiao, M Bi, T Tang, D Kong, M Diao… - Ageing Research …, 2022 - Elsevier
… , K ATP channels have been found to be expressed in … -terminus via the extracellular
pore-forming region. M1 contains the … Abnormal expression of Kir6.2 in hippocampal CA1 …

Sulfonylurea receptor 1, transient receptor potential cation channel subfamily M member 4, and KIR6. 2: role in hemorrhagic progression of contusion

V Gerzanich, JA Stokum, S Ivanova, SK Woo… - Journal of …, 2019 - liebertpub.com
… about SUR1's potential pore-forming subunit partners. Two … , corpus callosum and
hippocampus with normal-appearing … also express SUR1 as part of K ATP channels, and SUR1 in …

[HTML][HTML] Ion channel dysfunction in astrocytes in neurodegenerative diseases

S Wang, B Wang, D Shang, K Zhang, X Yan… - Frontiers in …, 2022 - frontiersin.org
… Such channels are composed of Kir6.1, Kir6.2 pore-forming … The Kir6.1 and 6.2 subunits of
K-ATP channels are both … astrocytes in both patients with AD and the hippocampus in 3 × Tg-…

[HTML][HTML] Kir6. 1/K-ATP channel in astrocytes is an essential negative modulator of astrocytic pyroptosis in mouse model of depression

F Li, SY Jiang, T Tian, WJ Li, Y Xue, RH Du, G Hu… - Theranostics, 2022 - ncbi.nlm.nih.gov
… the astrocytic Kir6.1 expression in hippocampus of mice. We … composed of pore-forming
Kir6.x (6.1 or 6.2) subunits and … Immuno-reactive bands were analyzed with ImageQuant™ LAS …