Systematic analysis of binding of transcription factors to noncoding variants

J Yan, Y Qiu, AM Ribeiro dos Santos, Y Yin, YE Li… - Nature, 2021 - nature.com
… matrices of most transcription factors lack sufficient predictive … transcription factors and
demonstrate their utility in genome-… covered by at least 20 allelic reads in ChIP–seq experiments …

[HTML][HTML] CiiiDER: A tool for predicting and analysing transcription factor binding sites

LJ Gearing, HE Cumming, R Chapman, AM Finkel… - PloS one, 2019 - journals.plos.org
… and enhancer regions of genomic DNA and either activate or … tools to be installed or lack
effective visualisations, providing … CiiiDER will read sequences directly from data entered in …

FactorNet: a deep learning framework for predicting cell type specific transcription factor binding from nucleotide-resolution sequential data

D Quang, X Xie - Methods, 2019 - Elsevier
genome-wide [1], and DNase-seq, which identifies genome-… between the presence and
absence of epigenetic markers, … measure as the fraction of reads that fall into conservative peaks …

Transcription factors: Bridge between cell signaling and gene regulation

P Weidemüller, M Kholmatov, E Petsalaki… - …, 2021 - Wiley Online Library
… TF binding sites in the genome, using tools like PWMscan [67], … transcriptional states and
response to signaling. However, the exact nature of these networks is unknown and we still lack

Accurate prediction of cell type-specific transcription factor binding

J Keilwagen, S Posch, J Grau - Genome biology, 2019 - Springer
… -DREAM in vivo Transcription Factor Binding Site Prediction … for a total of 31 transcription
factors in 22 primary cell types and … peaks are available due to the lack of replicates. In such …

Building transcription factor binding site models to understand gene regulation in plants

X Lai, A Stigliani, G Vachon, C Carles, C Smaczniak… - Molecular plant, 2019 - cell.com
Transcription factors (TFs) are key cellular components that … of the genome where they can
recruit transcriptional co-factors … Therefore, the identification of TFBSs in genomic sequences …

hTFtarget: a comprehensive database for regulations of human transcription factors and their targets

Q Zhang, W Liu, HM Zhang, GY Xie… - Genomics …, 2020 - academic.oup.com
… clean reads to human reference genome GRCh38. Datasets with <5 million reads after the
… (IgG samples were used as controls only at the absence of input samples). The peak calling …

Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome

S Lago, M Nadai, FM Cernilogar, M Kazerani… - Nature …, 2021 - nature.com
… enriched in ChIP sample (~55%) vs the whole genome 44 (~41… p value < 0.001, **p value
< 0.01, the absence of asterisks … seq reads were aligned to the human reference genome with …

Global reference mapping of human transcription factor footprints

J Vierstra, J Lazar, R Sandstrom, J Halow, K Lee… - Nature, 2020 - nature.com
… million compact genomic elements that encode transcription factor … Currently we lack a
comprehensive, nucleotide-resolution … , with a mean of 4.3 footprints per DHS with sufficient read

JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles

JA Castro-Mondragon, R Riudavets-Puig… - Nucleic acids …, 2022 - academic.oup.com
… Since plant genomes contain many classes of TFs absent from TFClass, we expanded the
TF structural classification using TFClass guidelines (39) and published structural evidence (…