Systematic analysis of binding of transcription factors to noncoding variants
… matrices of most transcription factors lack sufficient predictive … transcription factors and
demonstrate their utility in genome-… covered by at least 20 allelic reads in ChIP–seq experiments …
demonstrate their utility in genome-… covered by at least 20 allelic reads in ChIP–seq experiments …
[HTML][HTML] CiiiDER: A tool for predicting and analysing transcription factor binding sites
… and enhancer regions of genomic DNA and either activate or … tools to be installed or lack
effective visualisations, providing … CiiiDER will read sequences directly from data entered in …
effective visualisations, providing … CiiiDER will read sequences directly from data entered in …
FactorNet: a deep learning framework for predicting cell type specific transcription factor binding from nucleotide-resolution sequential data
… genome-wide [1], and DNase-seq, which identifies genome-… between the presence and
absence of epigenetic markers, … measure as the fraction of reads that fall into conservative peaks …
absence of epigenetic markers, … measure as the fraction of reads that fall into conservative peaks …
Transcription factors: Bridge between cell signaling and gene regulation
P Weidemüller, M Kholmatov, E Petsalaki… - …, 2021 - Wiley Online Library
… TF binding sites in the genome, using tools like PWMscan [67], … transcriptional states and
response to signaling. However, the exact nature of these networks is unknown and we still lack …
response to signaling. However, the exact nature of these networks is unknown and we still lack …
Accurate prediction of cell type-specific transcription factor binding
J Keilwagen, S Posch, J Grau - Genome biology, 2019 - Springer
… -DREAM in vivo Transcription Factor Binding Site Prediction … for a total of 31 transcription
factors in 22 primary cell types and … peaks are available due to the lack of replicates. In such …
factors in 22 primary cell types and … peaks are available due to the lack of replicates. In such …
Building transcription factor binding site models to understand gene regulation in plants
… Transcription factors (TFs) are key cellular components that … of the genome where they can
recruit transcriptional co-factors … Therefore, the identification of TFBSs in genomic sequences …
recruit transcriptional co-factors … Therefore, the identification of TFBSs in genomic sequences …
hTFtarget: a comprehensive database for regulations of human transcription factors and their targets
… clean reads to human reference genome GRCh38. Datasets with <5 million reads after the
… (IgG samples were used as controls only at the absence of input samples). The peak calling …
… (IgG samples were used as controls only at the absence of input samples). The peak calling …
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
S Lago, M Nadai, FM Cernilogar, M Kazerani… - Nature …, 2021 - nature.com
… enriched in ChIP sample (~55%) vs the whole genome 44 (~41… p value < 0.001, **p value
< 0.01, the absence of asterisks … seq reads were aligned to the human reference genome with …
< 0.01, the absence of asterisks … seq reads were aligned to the human reference genome with …
Global reference mapping of human transcription factor footprints
J Vierstra, J Lazar, R Sandstrom, J Halow, K Lee… - Nature, 2020 - nature.com
… million compact genomic elements that encode transcription factor … Currently we lack a
comprehensive, nucleotide-resolution … , with a mean of 4.3 footprints per DHS with sufficient read …
comprehensive, nucleotide-resolution … , with a mean of 4.3 footprints per DHS with sufficient read …
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
JA Castro-Mondragon, R Riudavets-Puig… - Nucleic acids …, 2022 - academic.oup.com
… Since plant genomes contain many classes of TFs absent from TFClass, we expanded the
TF structural classification using TFClass guidelines (39) and published structural evidence (…
TF structural classification using TFClass guidelines (39) and published structural evidence (…