… of acid sphingomyelinase or neutral sphingomyelinase 2 or 3 … MDMs were transfected with
scrambled RNA (scRNA) or … Sphingomyelin levels in the plasma membrane are regulated …

… As controls, cells were transfected with a control RNA having a scrambled nucleotide
sequence. The … that alter the lipid composition of the plasma membrane could play a role in the …

… deepen our knowledge about platelet lipids regulating thrombo-… by regulating granule
secretion and platelet aggregation for … is the identification of acid sphingomyelinase (SMPD1) as a …

… Platelets were shown to secrete ASMase upon thrombin … blunted platelet degranulation
and thrombus formation in the … the plasma membrane and whose expression is regulated by …

… can release sphingomyelinases, such as acid sphingomyelinase (ASMase), that can breakdown
SM in the plasma membrane. … reagent (vehicle), scrambled oligonucleotide (scRNA), or …

… SM on the plasma membrane is regulated in response to … PS scrambling, we conducted in
vitro cell experiments. … the changes in cell surface SM induced by bacterial sphingomyelinase (…

… of lipids within the eukaryotic cell membrane that have been … via the inhibition of acid
sphingomyelinase, which hydrolyzes … to regulate the proliferation and migration of assorted cell …

… regulate tubulin polymerization and EB3 binding in platelets … intracellular Ca 2+ release and
thrombus formation [29]. … known to regulate the assembly and activity of plasma membrane-…

… by incorporating them from plasma or recycling plasma membrane sphingomyelins, both …
with healthy controls (data not shown). We hypothesize that impaired platelet formation may, in …

… aliquot of the aqueous phase to determine the release of [ 14 C]… , the platelet contribution to
clot formation was significantly … in the setting of normal acid sphingomyelinase activity may be …