Functional Consequences of CFTR Interactions in Cystic Fibrosis

Y Ramananda, AP Naren, K Arora - International Journal of Molecular …, 2024 - mdpi.com
… the submucosal gland acini [209]. Mucous cells on the airway surface produce and secrete
… the titration and fine-tuning of CFTR-dependent physiological responses to various envi…

[HTML][HTML] Disrupted local innervation results in less VIP expression in CF mice tissues

A Semaniakou, S Brothers, G Gould… - Journal of Cystic …, 2021 - Elsevier
… , mostly by regulating CFTR-dependent secretions [8,9]. … -bronchial smooth muscle, around
submucosal glands and … exocrine glands, including sweat gland acini, respiratory epithelium, …

[PDF][PDF] Hyperconcentrated Mucus Unifies Submucosal Gland and Superficial Airway Dysfunction in Cystic Fibrosis

P Core - scholar.archive.org
acini, respectively (Fig.4C). SMG mucus passing through … forces, a product of abnormal
CFTR-dependent mucus hydration (… , and liquid secretion by airway submucosal glands. The …

Bicarbonate permeation through anion channels: its role in health and disease

DH Shin, M Kim, Y Kim, I Jun, J Jung, JH Nam… - … -European Journal of …, 2020 - Springer
… 3 − secretion by airway epithelia and submucosal glands … , such as in pancreatic and salivary
gland acinar cells [61, 85], [Ca … Furthermore, reduced CFTR-dependent HCO 3 − secretion

Animal models of cystic fibrosis in the era of highly effective modulator therapies

BR Grubb, A Livraghi-Butrico - Current opinion in pharmacology, 2022 - Elsevier
… For examples, airway submucosal glands are associated … potential for intrinsic, CFTR-dependent
drivers of inflammation. … of the digestive enzymes secreted by acinar cells and impairs …

[HTML][HTML] TMEM16A in cystic fibrosis: activating or inhibiting?

K Kunzelmann, J Ousingsawat, I Cabrita… - Frontiers in …, 2019 - frontiersin.org
… Taken together, TMEM16A supports fluid secretion by ciliated airway epithelial cells, but …
, although mouse airways show differences in structure, distribution of submucosal glands and …

CHANGES IN VASOACTIVE INTESTINAL PEPTIDE (VIP) AMOUNT IN CYSTIC FIBROSIS

P Semaniakou - 2020 - dalspace.library.dal.ca
submucosal glands of the conducting airways, stimulating … In pancreatic acinar cells Cl-
secretion is performed through … , fluid secretion from serous cells is CFTR-dependent while …

[HTML][HTML] Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

J Llinares, A Cantereau, L Froux, F Becq - Plos one, 2020 - journals.plos.org
… two ion channels are involved in Airway Surface Liquid (ASL) … The majority of non
CFTR-dependent chloride conductances … epithelium and acinar cells forming submucosal glands

[HTML][HTML] Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

J Xu, A Livraghi-Butrico, X Hou, C Rajagopalan… - JCI insight, 2021 - ncbi.nlm.nih.gov
airway superficial epithelium versus submucosal glands [SMG] in … due to defective
CFTR-dependent airway mucus clearance. … Abnormal pancreatic acinar function, as suggested by …

[PDF][PDF] Restoring Airway Function in Muco-obstructive Diseases by Modulating TMEM16A and SLC26A9

RM Centeio - 2022 - scholar.archive.org
… , larger airways (diameter > 2 mm), submucosal glands (SMG… acinar cells of salivary and
pancreatic glands, airway smooth … cAMP-mediated (CFTRdependent) Cl- secretion, was firstly …