Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain

Y Zhang, N Song, F Liu, J Lin, M Liu, C Huang… - International journal of …, 2019 - nature.com
… neuralgia, temporomandibular joint disorders, migraine and … found that inflammatory orofacial
allodynia in rats was related … NK1 receptors are expressed in both neurons and SGCs, so …

Role of neuropeptides in orofacial pain: A literature review

J Wang, X Liu, J Gou, J Deng, M Li… - Journal of Oral …, 2024 - Wiley Online Library
pain encompasses dental pain, temporomandibular joint (… A mice experiment demonstrated
that CGRP upregulated … C; SP, substance P; TRPM3, transient receptor potential cation …

Role of neurotrophins in orofacial pain modulation: a review of the latest discoveries

F Bonomini, G Favero, S Castrezzati… - International journal of …, 2023 - mdpi.com
allodynia of the inflamed temporomandibular joint (TMJ) in … in an inflammatory soup-induced
trigeminal allodynia in a rat … upregulates TrkB through a paracrine/autocrine mechanism, …

Ion channels involved in substance P-mediated nociception and antinociception

CT Chang, BY Jiang, CC Chen - International Journal of Molecular …, 2019 - mdpi.com
… effector systems underlying neurokinin 1 receptors (NK1Rs) in … in rodents produced chronic
and bilateral mechanical … sensory neurons in an autocrine or paracrine manner. In the PNS…

The role of transient receptor potential (TRP) channels in the transduction of dental pain

MZ Hossain, MM Bakri, F Yahya, H Ando… - International journal of …, 2019 - mdpi.com
mice exhibit a thermal response similar to wild-type mice [100]. … from the facial skin and
temporomandibular joint [105,129,130]… mRNAs for substance P and its receptor neurokinin-1 has …

Neuroimmune interactions in painful TMD: mechanisms and treatment implications

Y Yi, X Zhou, X Xiong, J Wang - Journal of Leukocyte Biology, 2021 - academic.oup.com
… of temporomandibular joint (TMJ), and neurogenic … rat model, TNF-α promotes nociception
in trigeminal ganglia … peptide (CGRP), substance P (SP), and so on, and contribute to local …

Peripheral and central mechanisms of persistent orofacial pain

M Shinoda, A Kubo, Y Hayashi, K Iwata - Frontiers in Neuroscience, 2019 - frontiersin.org
… 2 receptor pathway following temporomandibular jointtrigeminal nerve injury in rats, and
they are involved in ectopic … that it binds the neurokinin 1 receptor expressed in macrophages, …

Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies

N Chuinsiri, D Edwards, V Telezhkin, CJ Nile… - Archives of Oral …, 2021 - Elsevier
… Calcitonin gene-related peptide (CGRP) and substance P were … on orofacial mechanical
sensitivity and SP expression in rats. … The paracrine effect of CGRP has been shown on satellite …

Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

K Messlinger, LK Balcziak, AF Russo - Journal of neural transmission, 2020 - Springer
… of neurokinin-1 (NK1) receptors, receptors for substance P, has indirectly been shown by
functional studies in the rat trigeminal ganglion. … temporomandibular joint and facial skin was …

Multi-dimensional role of the parabrachial nucleus in regulating pain-related affective disturbances in trigeminal neuropathic pain

A Katagiri, T Kato - Journal of Oral Science, 2020 - jstage.jst.go.jp
… tissues, including the temporomandibular joint and masseter … related peptide (CGRP),
substance P, and neuropeptide Y are … tion to the rat brain stem sensory trigeminal nuclear complex …