A review on caspases: key regulators of biological activities and apoptosis

G Sahoo, D Samal, P Khandayataray… - Molecular neurobiology, 2023 - Springer
… elegans and CED-4 protein is the stimulator for CED-3 activation while the CED-9 protein is
… zymogens and contain long pro-domains which allow them to interact with specific signalling …

Caspases—at the cutting edge of cell death

HR Stennicke - Programmed Cell Death in Animals and Plants, 2021 - taylorfrancis.com
… shows numerous features that bear more resemblance to the serine proteases than to other
… (1997) Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity. …

The intricate biophysical puzzle of caspase-1 activation

NJ Makoni, MR Nichols - Archives of biochemistry and biophysics, 2021 - Elsevier
… 11 are activated by the non-canonical inflammasome pathway … idea that a protease with a
particular substrate specificity was … IDL, while activation of other caspases involves removal of …

Characterization of Caspase 1 Substrate Specificity Utilizing Luminescent Reporter Constructs

N Rohlfes - 2020 - search.proquest.com
… biosensor measuring protease activation has been used … is also non-canonical inflammasomes
that can be activated … the cleavage of the pro-caspase 7 protein by active caspase 1…

[HTML][HTML] The role of caspase family in acute brain injury: the potential therapeutic targets in the future

A Zhang, Z Zhang, Y Liu, C Lenahan, H Xu… - Current …, 2022 - ncbi.nlm.nih.gov
… -8 activates the apoptotic pathway by cleaving pro-caspase-3 and pro-caspase-7 [21]. …
Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor, which has been tested in the …

[PDF][PDF] Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation

SS Burgener, NGF Leborgne, SJ Snipas, GS Salvesen… - Cell reports, 2019 - cell.com
… Serpinb6a inhibit the granule serine protease cathepsin G to … PR3 can directly activate
apoptotic pro-caspase-7 and pro-… cells through blockade of cell-specific, CatG-dependent RCD. …

[HTML][HTML] Application of regulatory cell death in cancer: based on targeted therapy and immunotherapy

X Qi, Q Li, X Che, Q Wang, G Wu - Frontiers in immunology, 2022 - frontiersin.org
… the cysteinyl aspartate specific proteinase (caspase) … and non-canonical inflammasome
pathways are the activation of … the activation of pro-caspase-3 and pro-caspase-7 forming …

Programmed cell death in animals and plants

J Bryant, J Garland, SG Hughes - 2021 - books.google.com
… to relate specific apoptotic events or cytokine activation to specific caspases. … features that
bear more resemblance to the serine proteases than to other well described thiol proteases

Exploring proteomic drug targets, therapeutic strategies and protein-protein interactions in cancer: mechanistic view

KB Dar, AH Bhat, S Amin, S Anjum… - Current cancer drug …, 2019 - ingentaconnect.com
… proteomics provides clear evidence about cell type-specific … This activated AKT has a
critical role in role in cell survival … Modifications involve incorporation of non-canonical amino …

Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner

E De Silva, DV Devine, E Jan, CD Roskelley… - Biochemical …, 2022 - portlandpress.com
… a platelet-specific FLNA deficiency … activates the effector caspases, pro-caspase-7 and -3,
to target and destroy cellular proteins [19]. Morphological features of platelet apoptosis include